Proceedings from a daylong symposium featuring key clinical presentations and papers in breast cancer, gastrointestinal cancers, genitourinary cancers, multiple myeloma, non-small cell lung cancer and Hodgkin and non-Hodgkin lymphoma, including chronic lymphocytic leukemia. Including perspectives from Drs Rafael Fonseca, Nikhil C Munshi, Andrew M Evens, Sonali M Smith, Owen A O’Connor, Andrew D Zelenetz, Jyoti D Patel, Lecia V Sequist, Tanios Bekaii-Saab, Andrew X Zhu, Al B Benson III, Axel Grothey, Harold J Burstein, Hope S Rugo, Daniel J George and Matthew R Smith. (Video Program)