Statement of Educational Need (Purpose)
Lung cancer is a devastating disease that accounts for more cancer-related deaths among both men and women than any other tumor type. Historically, systemic therapeutic options have been limited, but recent advances in our understanding of cellular and tumor biology have resulted in the development of numerous therapies demonstrating benefit in lung cancer. Despite these advances, many clinical scenarios continue to exist in which multiple treatment options may be available but the optimal strategy is highly debatable and may depend on rapidly evolving clinical research data. Consequently, a critical need remains for educational activities targeting the data-rich and dynamic field of lung cancer treatment.
TARGET AUDIENCE
This activity is intended for medical oncologists, hematologists, hematology-oncology fellows, nurses, thoracic surgeons, radiation oncologists and other healthcare providers involved in the treatment of non-small cell lung cancer (NSCLC).
LEARNING STRATEGIES FOR PARTICIPANTS
The information presented at this educational activity should improve your ability to:
- Develop an evidence-based treatment plan for localized NSCLC, exploring the roles of neoadjuvant and adjuvant systemic therapy.
- Apply the results of emerging clinical research to the recommendation of multimodality therapy for Stage III NSCLC.
- Counsel patients with advanced NSCLC about the benefits and risks of chemotherapy when administered alone or in combination with a biologic agent.
- Recognize the effect of performance status and physiologic age on the efficacy and safety of existing and emerging treatments for NSCLC.
- Identify patients with metastatic NSCLC who are likely to benefit from a cytotoxic and/or biologic maintenance therapeutic approach.
- Use tumor histology and clinical/molecular predictors of response and resistance to individualize treatment for lung cancer.
- Select appropriate prophylactic and/or acute clinical management strategies to reduce or ameliorate toxicities associated with VEGF and EGFR inhibitors.
- Differentiate among existing and emerging molecular-targeted therapies, and effectively integrate new compounds, when available, into the individualized NSCLC treatment algorithm.
- Formulate management strategies for limited- or extensive-stage small cell lung cancer, considering the contributory roles of surgery, radiation therapy (local and prophylactic cranial irradiation) and chemotherapy.
- Recall the design of ongoing clinical trials evaluating novel investigational agents in lung cancer, and counsel appropriately selected patients about availability and participation.
HOW TO USE THIS CME ACTIVITY
This CME activity consists of a video component. To receive credit, the participant should watch the video content and complete the Post-test and Educational Assessment and Credit Form located on our website at ResearchToPractice.com/WLCC2011Video/CME.
ACCREDITATION STATEMENT
The School of Medicine of The University of North Carolina at Chapel Hill is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CREDIT STATEMENT
The School of Medicine of The University of North Carolina at Chapel Hill designates this enduring activity for a maximum of 4.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
UNLABELED/UNAPPROVED USES NOTICE
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. The University of North Carolina at Chapel Hill does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the sponsors or grantors. Speakers who incorporate information about off-label or investigational use of drugs or devices have been asked to disclose that information.
DISCLOSURE STATEMENT
In accordance with the ACCME Essentials and Standards, everyone involved in planning or presenting this educational activity was required to disclose any relevant financial relationships with commercial interests in the healthcare industry. In addition, speakers who incorporate information about off-label or investigational use of drugs or devices have been asked to disclose that information.
No UNC CME staff member involved in the planning of this activity has any financial relationships to disclose.
The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.
FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:
Walter J Curran Jr, MD
Executive Director
Winship Cancer Institute
Lawrence W Davis Professor and Chair
Department of Radiation Oncology
Emory University
Atlanta, Georgia
Advisory Committee: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company; Consulting Agreements: Bayer HealthCare Pharmaceuticals, Lilly USA LLC; Paid Research: Abbott Laboratories, Pfizer Inc.
Giuseppe Giaccone, MD, PhD
Bethesda, Maryland
No real or apparent conflicts of interests to disclose.
John Heymach, MD, PhD
Associate Professor of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas
Consulting Agreements: AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc, Genentech BioOncology, GlaxoSmithKline, Pfizer Inc; Paid Research: AstraZeneca Pharmaceuticals LP, GlaxoSmithKline, Pfizer Inc.
Karen Kelly, MD
Professor of Medicine
UC Davis Cancer Center
Sacramento, California
Advisory Committee: Allos Therapeutics, Bayer HealthCare Pharmaceuticals, Biodesix, Genentech BioOncology, GlaxoSmithKline, Pfizer Inc.
Edward S Kim, MD
Associate Professor of Medicine
Chief, Section of Head and Neck Medical Oncology
Director, Clinical Research Operations
Department of Thoracic/Head and Neck Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas
Advisory Committee: Bayer HealthCare Pharmaceuticals, Onyx Pharmaceuticals Inc; Consulting Agreements: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Onyx Pharmaceuticals Inc; Paid Research: Genentech BioOncology, Lilly USA LLC, OSI Oncology.
Rogerio C Lilenbaum, MD
Director, Thoracic Oncology Program
The Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida
Voluntary Professor of Medicine
University of Miami Miller School of Medicine
Miami, Florida
Consulting Agreements: Abraxis BioScience Inc, a wholly owned subsidiary of Celgene Corporation, Genentech BioOncology; Stock Ownership: YM BioSciences Inc.
Thomas J Lynch Jr, MD
Director, Yale Cancer Center
Physician-in-Chief, Smilow Cancer
Hospital at Yale New Haven
New Haven, Connecticut
Board of Directors: Infinity Pharmaceuticals Inc; Consulting Agreements: Boehringer Ingelheim Pharmaceuticals Inc, SuperGen Inc; Stock Ownership: Biogen Idec, Infinity Pharmaceuticals Inc.
Vincent A Miller, MD
Associate Attending Physician
Thoracic Oncology Service
Memorial Sloan-Kettering Cancer Center
New York, New York
Advisory Committee: Cylene Pharmaceuticals, Sanofi; Consulting Agreements: Allos Therapeutics, ArQule, Boehringer Ingelheim Pharmaceuticals Inc, Genentech BioOncology, Lilly USA LLC, Nereus Pharmaceuticals Inc, Pfizer Inc; Honoraria: ArQule, Nereus Pharmaceuticals Inc; Paid Research: Boehringer Ingelheim Pharmaceuticals Inc, Exelixis Inc, Genentech BioOncology, Pfizer Inc.
Ronald B Natale, MD
Director, Lung Cancer Clinical Research Program
Acting Director, Phase I Clinical Trials Unit
Samuel Oschin Comprehensive Cancer Institute
Cedars-Sinai Medical Center
Los Angeles, California
Advisory Committee: Amgen Inc, Boehringer Ingelheim Pharmaceuticals Inc, Pfizer Inc; Consulting Agreements: Genentech BioOncology, Lilly USA LLC; Paid Research: Lilly USA LLC, Novartis Pharmaceuticals Corporation.
Harvey I Pass, MD
Professor of Surgery and Cardiothoracic Surgery
Director, Division of Thoracic Surgery
NYU Langone Medical Center
New York, New York
Paid Research: Pfizer Inc.
Mark A Socinski, MD
Professor of Medicine
Multidisciplinary Thoracic Oncology Program
Lineberger Comprehensive Cancer Center
University of North Carolina
Chapel Hill, North Carolina
Data and Safety Monitoring Board: Bayer HealthCare Pharmaceuticals; Paid Research: Abraxis BioScience Inc, a wholly owned subsidiary of Celgene Corporation, Celgene Corporation, Genentech BioOncology, GlaxoSmithKline, Lilly USA LLC, Pfizer Inc; Speakers Bureau: Genentech BioOncology, GlaxoSmithKline, Lilly USA LLC, Sanofi.
Everett E Vokes, MD
Chairman, Department of Medicine
John E Ultmann Professor of Medicine
and Radiation and Cellular Oncology
The University of Chicago
Chicago, Illinois
Advisory Committee: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, EMD Serono Inc, Genentech BioOncology, GlaxoSmithKline, ImClone Systems Incorporated, Lilly USA LLC, OSI Oncology, Pfizer Inc; Data and Safety Monitoring Board: Amgen Inc.
MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: Allos Therapeutics, Amgen Inc, AstraZeneca Pharmaceuticals LP, Aureon Laboratories Inc, Bayer HealthCare Pharmaceuticals/Onyx Pharmaceuticals Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Cephalon Inc, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, EMD Serono Inc, Genentech BioOncology, Genomic Health Inc, ImClone Systems, a wholly owned subsidiary of Eli Lilly and Company, Lilly USA LLC, Millennium — The Takeda Oncology Company, Mundipharma International Limited, Myriad Genetics Inc, Novartis Pharmaceuticals Corporation, OSI Oncology, Sanofi and Seattle Genetics.
EDUCATIONAL SUPPORT
This program is supported by educational grants from Bayer HealthCare Pharmaceuticals/Onyx Pharmaceuticals Inc, Celgene Corporation, Daiichi Sankyo Inc, Genentech BioOncology & OSI Oncology and Lilly USA LLC.
Hardware/Software Requirements:
An Internet connection that is at least 28.8 Kbps
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 6.x or newer, Firefox 2.x or newer, or Safari 2.x or newer
Macromedia Flash plug-in 6.0 or greater
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio
Last review date: June 2011
Expiration date: June 2012