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Oncology Grand Rounds Series: Part 4 — Chronic Lymphocytic Leukemia
Released June 2019

Video proceedings from the fourth in a series of 6 integrated symposia held at the 2019 ONS Annual Congress. Featuring perspectives from Dr Paul M Barr, Ms Josie Bazemore, Dr Nitin Jain and Ms Lynn Rich. (Video Program)

CE Disclosures and Faculty Information

    This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of chronic lymphocytic leukemia (CLL).

    In the United States, an estimated 20,720 new cases of CLL will be diagnosed in 2019, with 3,930 deaths attributed to the disease. Based on an improved understanding of the biology of CLL, over the past decade a number of novel agents and strategies have been investigated. Many of these efforts have proven to be successful, and the treatments in question are now available for routine use in the clinic. Similarly, a number of novel agents and rational combination approaches in clinical development are showing substantial promise and appear poised to disrupt classical treatment algorithms for CLL.

    With the many exciting advances that are rapidly occurring, however, a number of vexing questions and clinical challenges are simultaneously emerging as well. Although many of the educational needs related to the care of patients with CLL are relevant specifically to the practicing medical oncologists and hematologists directly responsible for therapeutic decision-making, prospective and retrospective patient-level research has shown that oncology nurses play an integral role in the successful delivery of systemic anticancer therapy and in the preservation of the physical and psychosocial well-being of patients. These video proceedings from the fourth part of a 6-part integrated CNE curriculum originally held at the 2019 ONS Annual Congress feature discussions with leading CLL investigators and their nursing counterparts regarding actual patient cases and recent clinical research findings affecting the optimal therapeutic and supportive care for patients with newly diagnosed and relapsed or refractory CLL.

    By providing information on the latest research developments in the context of expert perspectives, this CNE activity will assist oncology nurses, nurse practitioners and clinical nurse specialists with the formulation of state-of-the-art clinical management strategies to facilitate optimal care of patients with CLL.


    • Provide patient education to enhance clinical decision-making regarding systemic agents available for the management of CLL.
    • Appreciate the contribution of patient performance status and comorbidities, biomarker profile and prior therapeutic exposure to the selection and sequencing of systemic therapy for newly diagnosed and relapsed/refractory CLL.
    • Design and implement a plan of care to recognize and manage side effects and toxicities associated with existing and recently approved systemic therapies for patients with CLL to support quality of life and continuation of therapy.
    • Appreciate available data with and consider the potential clinical roles of novel agents and regimens that may soon provide patients with treatment options beyond the initial indications.
    • Recall available and emerging data with other investigational agents, regimens and immunotherapeutic strategies currently in Phase III testing for CLL, and, where applicable, refer eligible patients for clinical trial participation or expanded access programs.
    • Identify opportunities to enhance the collaborative role of oncology nurses in the comprehensive biopsychosocial care of patients with CLL to optimize clinical and quality-of-life outcomes.

    Research To Practice (RTP) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

    CNE credit is no longer available for this issue

    CNE credit is no longer available for this issue

    This CNE activity consists of a video component.
    CNE credit is no longer available for this issue

    RTP is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CNE activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Paul M Barr, MD
    Medical Director, Clinical Trials Office
    Associate Professor of Medicine
    Wilmot Cancer Institute
    University of Rochester Medical Center
    Rochester, New York

    Advisory Committee: AbbVie Inc, AstraZeneca Pharmaceuticals LP, Celgene Corporation, Genentech, Gilead Sciences Inc, Janssen Biotech Inc, Merck, Pharmacyclics LLC, an AbbVie Company; Consulting Agreement: Seattle Genetics; Data and Safety Monitoring Board/Committee: TG Therapeutics Inc.

    Josie Bazemore, MSN, AGPCNP-BC
    Dana-Farber Cancer Institute
    Boston, Massachusetts

    Advisory Committee: Janssen Biotech Inc.

    Nitin Jain, MD
    Associate Professor of Medicine
    Department of Leukemia
    The University of Texas MD Anderson Cancer Center
    Houston, Texas

    Advisory Committee and Consulting Agreements: AbbVie Inc, Adaptive Biotechnologies, AstraZeneca Pharmaceuticals LP, Janssen Biotech Inc, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company; Contracted Research: AbbVie Inc, Adaptive Biotechnologies, ADC Therapeutics SA, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Celgene Corporation, Cellectis, Genentech, Incyte Corporation, Janssen Biotech Inc, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Servier; Data and Safety Monitoring Board/Committee: Janssen Biotech Inc.

    Lynn Rich, RN, MSN, OCN, BC-ANP
    University of Rochester
    Wilmot Cancer Institute
    Lymphoma Program
    Rochester, New York

    No relevant conflicts of interest to disclose.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME/CNE activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    RTP CNE PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for RTP have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from AbbVie Inc, Genentech, Pharmacyclics LLC, an AbbVie Company and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: June 2019
    Expiration date: June 2020

    There is no implied or real endorsement of any product by RTP or the American Nurses Credentialing Center.

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