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Data + Perspectives: Clinical Investigators Explore Emerging Research and Actual Patients with Uterine Sarcomas
Released June 2019

A special audio program developed from an independent satellite symposium during the Society of Gynecologic Oncology’s 2019 Annual Meeting on Women’s Cancer. Featuring perspectives from Drs Amanda Nickles Fader, Mario M Leitao Jr, Angeles Alvarez Secord and Brian A Van Tine. (Audio Program)

CE Disclosures and Faculty Information

    This activity is intended for gynecologic oncologists, medical oncologists, gynecologists and other healthcare providers involved in the treatment of gynecologic cancers.

    Sarcomas of the female genital tract are uncommon neoplasms with an estimated incidence ranging between 1% and 7% of all gynecologic cancers. Although sarcomas may occur in any organ of the female genitalia (uterine corpus, cervix, ovary, fallopian tubes, vulva and vagina), the highest occurrence is in the uterine corpus. It is estimated that 61,880 new cases of cancer of the uterine corpus will be diagnosed in 2019 and 12,160 will die of this disease. Based on the cell of origin, uterine sarcomas can be further divided into leiomyosarcoma, endometrial stromal sarcoma and mixed mesodermal tumors. The most common of these is uterine leiomyosarcoma (uLMS), an aggressive cancer characterized by poor prognosis and high recurrence rates. As with the treatment paradigm for many other solid tumors, surgery remains a critical component in the primary management of localized disease (Stage I and II).

    As a group gynecologic sarcomas are relatively rare, and given their heterogeneity, specific histologic subtypes present even less frequently in clinical practice. Therefore, gynecologic and medical oncologists may lack experience caring for patients with any given uterine sarcoma, including uLMS. And although conventional treatment options for sarcomas of the female genital tract remained unchanged for several years, recent research has led to a number of FDA-approved therapies that have begun to disrupt established practices.

    This CME program, developed from the proceedings of a satellite symposium held during the 2019 Society of Gynecologic Oncology Annual Meeting on Women’s Cancer, features discussions with leading researchers with expertise in gynecologic cancers regarding actual cases from their practices and the published data that drive clinical decision-making. By providing information on emerging research developments and their potential application to routine practice, this activity is designed to assist medical oncologists, gynecologic oncologists and other healthcare providers with the formulation of up-to-date clinical management strategies.


    • Appreciate the importance of multidisciplinary collaboration in the diagnosis and management of gynecologic sarcomas, and use this information to design a process to optimize tissue procurement, accurate histologic assessment, tertiary care referral and treatment outcome.
    • Develop an evidence-based strategy for the treatment of Stage I to III uterine sarcoma, considering the potential contributions of surgery, radiation therapy and cytotoxic therapy.
    • Employ guideline-endorsed monitoring protocols and techniques to effectively screen patients with localized uLMS for the development of metastases.
    • Appraise available safety and efficacy data with approved targeted and cytotoxic therapies used in the treatment of advanced gynecologic sarcomas, and consider how these agents can be optimally incorporated into clinical management algorithms.
    • Recognize the toxicities and adverse events associated with novel agents in the management of soft-tissue sarcomas, and formulate strategies to minimize and manage these side effects.
    • Recall new data with other investigational agents demonstrating promising activity in uterine and other gynecologic sarcomas, and discuss ongoing trial opportunities with eligible patients.

    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    Research To Practice designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Please note, this program has been specifically designed for the following ABIM specialty: medical oncology.

    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/GynOnc19/Sarcoma/CME.

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Amanda Nickles Fader, MD
    Associate Professor and Director
    The Kelly Gynecologic Oncology Service
    Director, Center for Rare Gynecologic Cancers
    Johns Hopkins School of Medicine
    Baltimore, Maryland

    Advisory Committee: Clovis Oncology, Merck.

    Mario M Leitao Jr, MD
    Attending Surgeon and Member, Division of Gynecology
    Professor, Weill Cornell Medical College
    Director, Gynecologic Oncology Fellowship Program
    Director, Minimal Access and Robotic Surgery Program
    Department of Surgery
    Memorial Sloan Kettering Cancer Center
    New York, New York

    No relevant conflicts of interest to disclose.

    Angeles Alvarez Secord, MD, MHSc
    Professor, Duke Cancer Institute
    Duke University Health System
    Durham, North Carolina

    Advisory Committee: AstraZeneca Pharmaceuticals LP, Clovis Oncology, Genentech, Janssen Biotech Inc, Merck, Roche Laboratories Inc; Contracted Research: AbbVie Inc, Amgen Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Clovis Oncology, Eisai Inc, Exelixis Inc, Genentech, Immutep Ltd, Incyte Corporation, Merck, Roche Laboratories Inc, Seattle Genetics, Tesaro.

    Brian A Van Tine, MD, PhD
    Medical Oncology
    Associate Professor of Medicine
    Sarcoma Program Director
    Washington University in St Louis
    Siteman Cancer Center
    St Louis, Missouri

    Advisory Committee and Consulting Agreements: Adaptimmune, CytRx Corporation, Daiichi Sankyo Inc, Epizyme Inc, Immune Design, Janssen Biotech Inc, Lilly, Pfizer Inc; Contracted Research: Merck, Pfizer Inc, TRACON Pharmaceuticals Inc; Speakers Bureau: Adaptimmune, Caris Life Sciences, Janssen Biotech Inc, Lilly; Other Remunerated Activities: Merck, Pfizer Inc, TRACON Pharmaceuticals Inc.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.

    This activity is supported by an educational grant from Lilly.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: June 2019
    Expiration date: June 2020

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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Data + Perspectives: Clinical Investigators Explore Emerging Research and Actual Patients with Uterine Sarcomas
Released June 2019

A special audio program developed from an independent satellite symposium during the Society of Gynecologic Oncology’s 2019 Annual Meeting on Women’s Cancer. Featuring perspectives from Drs Amanda Nickles Fader, Mario M Leitao Jr, Angeles Alvarez Secord and Brian A Van Tine. (Audio Program)

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