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Novel Agents and Emerging Strategies in the Management of Gynecologic Cancers
Released June 2019

A special audio program developed from an independent satellite symposium during the Society of Gynecologic Oncology’s 2019 Annual Meeting on Women’s Cancer. Featuring perspectives from Dr Michael J Birrer, David M O’Malley, Matthew A Powell and Shannon N Westin. (Audio Program)

CE Disclosures and Faculty Information

    This activity is intended for gynecologic oncologists, medical oncologists, gynecologists and other healthcare providers involved in the treatment of gynecologic cancers.

    The pace of oncology drug development has accelerated in recent years to previously unmatched rates. Fueled by an increased understanding of the biologic underpinnings of tumor development and growth, clinical research focused on the potential benefits of novel targeted therapeutic agents with unique mechanisms of action and safety profiles has improved outcomes in myriad large and rigorous clinical trials across many tumor types. The successes yielded by this rational approach to the design and evaluation of therapies have in turn provided oncology healthcare professionals and patients with new FDA-endorsed treatment options. Although this dynamic is evident in many areas of oncology, recent advances in the management of gynecologic cancers (ovarian, cervical and endometrial cancer) have made it particularly important in this corner of medicine. A plethora of extremely promising data sets have recently emerged, stirring significant enthusiasm for the possibility that several more novel approaches may soon become available to practicing clinicians. Existing management algorithms for these gynecologic cancers are poised for further change, and it is therefore critical that continuing education be offered to all practitioners involved in patient care.

    This CME program was developed from the proceedings of a satellite symposium held during the Society of Gynecologic Oncology’s 2019 Annual Meeting on Women’s Cancer. It features leading gynecologic cancer researchers discussing actual cases from their practices and the published data that drive clinical decision-making for patients in those and diverse other situations. By providing information on the latest research developments and their potential application to routine practice, this activity is designed to assist medical oncologists, gynecologic oncologists and other healthcare providers with the formulation of up-to-date clinical management strategies.


    • Review the mechanisms of action and emerging efficacy data with novel targeted agents under investigation for ovarian, endometrial and cervical cancer, and effectively prioritize clinical trial opportunities or expanded access programs for eligible patients.
    • Design and implement a plan of care to recognize and manage side effects and toxicities associated with novel and recently approved systemic therapies for patients with ovarian, endometrial and cervical cancer to support quality of life and continuation of therapy.
    • Recall the biologic rationale for, published research data with and ongoing clinical trials evaluating the use of immune checkpoint inhibitors in the management of gynecologic cancers, and identify patients who may be eligible for this strategy in or outside of a protocol setting.
    • Recognize the incidence of folate receptor alpha overexpression in patients with gynecologic cancers, and consider the potential role of novel agents designed to exploit this therapeutic target.

    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    Research To Practice designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Please note, this program has been specifically designed for the following ABIM specialty: medical oncology.

    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/GynOnc19/NovelAgents/CME.

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Michael J Birrer, MD, PhD
    Director, O’Neal Comprehensive Cancer Center
    Professor of Medicine/Hematology and Oncology
    Evalina B Spencer Chair in Oncology
    The University of Alabama at Birmingham
    Birmingham, Alabama

    No relevant conflicts of interest to disclose.

    David M O’Malley, MD
    Medical Director, Gynecologic Oncology
    Director, Clinical Research, Gynecologic Oncology
    Co-Director, Gynecologic Oncology Phase I Program
    ORIEN Physician Liaison for OSUCCC – James
    The Ohio State University and The James Cancer Center
    Columbus, Ohio

    Advisory Committee: AstraZeneca Pharmaceuticals LP, Clovis Oncology, GOG Foundation Inc, Janssen Biotech Inc, Myriad Genetic Laboratories Inc, Tesaro; Consulting Agreements: AbbVie Inc, Ambry Genetics, Amgen Inc, AstraZeneca Pharmaceuticals LP, Clovis Oncology, ImmunoGen Inc, Partnership for Health Analytic Research LLC, Tesaro; Contracted Research: Agenus Inc, Ajinomoto, Array BioPharma Inc, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Clovis Oncology, EMD Serono Inc, Ergomed PLC, Exelixis Inc, Genentech, GlaxoSmithKline, GOG Foundation Inc, ImmunoGen Inc, Janssen Biotech Inc, Ludwig Institute for Cancer Research Ltd, Novartis, PRA Health Sciences, Regeneron Pharmaceuticals Inc, Stemcentrx, Syneos Health, Tesaro, TRACON Pharmaceuticals Inc; Data and Safety Monitoring Board: Marker Therapeutics Inc.

    Matthew A Powell, MD
    Professor and Chief
    Division of Gynecologic Oncology
    Washington University School of Medicine
    St Louis, Missouri

    Consulting Agreements and Speakers Bureau: AstraZeneca Pharmaceuticals LP, Clovis Oncology, Merck, Tesaro.

    Shannon N Westin, MD, MPH
    Associate Professor
    Director, Early Drug Development
    Department of Gynecologic Oncology and Reproductive Medicine
    The University of Texas MD Anderson Cancer Center
    Houston, Texas

    Advisory Committee: AstraZeneca Pharmaceuticals LP, Clovis Oncology, Merck, Tesaro; Consulting Agreements: AstraZeneca Pharmaceuticals LP, Clovis Oncology, Genentech, Merck, Pfizer Inc, Roche Laboratories Inc, Takeda Oncology, Tesaro; Contracted Research: ArQule Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Clovis Oncology, Cotinga Pharmaceuticals, Genentech, Novartis, Roche Laboratories Inc, Tesaro; Data and Safety Monitoring Board/Committee: Syndax Pharmaceuticals Inc, Xenetic Biosciences Inc.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Eisai Inc, Genmab and Seattle Genetics, ImmunoGen Inc and Tesaro.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: June 2019
    Expiration date: June 2020

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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Listen to audio:
Novel Agents and Emerging Strategies in the Management of Gynecologic Cancers
Released June 2019

A special audio program developed from an independent satellite symposium during the Society of Gynecologic Oncology’s 2019 Annual Meeting on Women’s Cancer. Featuring perspectives from Dr Michael J Birrer, David M O’Malley, Matthew A Powell and Shannon N Westin. (Audio Program)

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