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Consensus or Controversy? Clinical Investigators Discuss the Optimal Management of Metastatic Renal Cell Carcinoma
Released April 2020

Proceedings from a CME symposium held at the 2020 Genitourinary Cancers Symposium. Featuring perspectives from Dr Toni K Choueiri, Dr Thomas E Hutson, Dr David F McDermott and Prof Thomas Powles. (Video Program)

CE Disclosures and Faculty Information

  • TARGET AUDIENCE
    This activity has been designed to meet the educational needs of medical and radiation oncologists, urologists and other allied healthcare professionals involved in the treatment of renal cell carcinoma (RCC).

    LEARNING OBJECTIVES

    • Effectively apply evidence-based research findings and other clinical and biologic factors in the best-practice selection of first-line therapy for patients with metastatic RCC (mRCC).
    • Recall the underlying research database supporting the FDA approval of first-line anti-PD-1/anti-CTLA-4 combination therapy for patients with mRCC, and develop strategies to appropriately integrate this treatment into the care of these individuals.
    • Appraise available clinical trial data evaluating the use of recently FDA-approved anti-PD-1/PD-L1 antibody/multikinase inhibitor combinations for patients with previously untreated mRCC, and counsel individuals with the disease regarding the risks and benefits of these novel regimens.
    • Develop a rational therapeutic approach to the sequencing of systemic therapies for patients with advanced RCC that progresses on first-line treatment, incorporating tyrosine kinase inhibitors, mTOR inhibitors, immunotherapeutic agents and other therapeutic approaches.
    • Recognize side effects and toxicities commonly associated with approved and investigational therapeutic approaches, and use this information to develop supportive care plans for patients with RCC undergoing treatment with these agents and regimens.
    • Recall available and emerging data with other investigational agents and strategies currently in testing for RCC, and where applicable, refer eligible patients for clinical trial participation.

    ACCREDITATION STATEMENT
    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CREDIT DESIGNATION STATEMENT
    Research To Practice designates this enduring material for a maximum of 2 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
    Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 2 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Please note, this program has been specifically designed for the following ABIM specialty: medical oncology.

    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    HOW TO USE THIS CME ACTIVITY
    This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/GUCancers20/RCC/CME.

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Toni K Choueiri, MD
    Director, Lank Center for Genitourinary Oncology
    Department of Medical Oncology
    Dana-Farber Cancer Institute
    Co-Leader, Kidney Cancer Program
    Dana-Farber/Harvard Cancer Center
    The Jerome and Nancy Kohlberg Professor of Medicine
    Harvard Medical School
    Boston, Massachusetts

    Advisory Committee and Consulting Agreements: Alexion Pharmaceuticals, Analysis Group, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, GlaxoSmithKline, Heron Therapeutics, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme; Contracted Research: Alexion Pharmaceuticals, Analysis Group, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Calithera Biosciences, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, Exelixis Inc, F Hoffmann-La Roche Ltd, Foundation Medicine, Genentech, GlaxoSmithKline, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme, Takeda Oncology, TRACON Pharmaceuticals Inc; Honoraria: Alexion Pharmaceuticals, Analysis Group, Apollo Endosurgery Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, EMD Serono Inc, Exelixis Inc, F Hoffmann-La Roche Ltd, Foundation Medicine, Genentech, GlaxoSmithKline, Heron Therapeutics, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme.

    Thomas E Hutson, DO, PharmD
    Director, GU Oncology Program
    Co-Director, Urologic Cancer Research and Treatment Center
    Texas Oncology
    Charles A Sammons Cancer Center
    Baylor University Medical Center
    Professor of Medicine
    Texas A&M HSC College of Medicine
    Dallas, Texas

    Advisory Committee, Consulting Agreements, Contracted Research and Speakers Bureau: Astellas, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Eisai Inc, EMD Serono Inc, Genentech, Merck, Novartis, Pfizer Inc.

    David F McDermott, MD
    Chief, Medical Oncology
    Beth Israel Deaconess Medical Center
    Leader, Kidney Cancer Program
    Dana-Farber/Harvard Cancer Center
    Professor of Medicine
    Harvard Medical School
    Boston, Massachusetts

    Consulting Agreements: Alkermes, Bristol-Myers Squibb Company, EMD Serono Inc, Lilly, Merck, Pfizer Inc; Contracted Research: Alkermes, Bristol-Myers Squibb Company, Exelixis Inc, Genentech, Merck, Novartis, Pfizer Inc, X4 Pharmaceuticals Inc.

    Thomas Powles, MBBS, MRCP, MD
    Professor of Genitourinary Oncology
    Barts Cancer Institute
    Director of Barts Cancer Centre
    Queen Mary University of London
    London, United Kingdom

    Consulting Agreements: Exelixis Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Seattle Genetics.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, a member of the Roche Group, Genmab, Genomic Health Inc, Gilead Sciences Inc, GlaxoSmithKline, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Eisai Inc, Exelixis Inc and Merck.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: April 2020
    Expiration date: April 2021

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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