CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This activity has been designed to meet the educational needs of medical and radiation oncologists, urologists and other allied healthcare professionals involved in the treatment of renal cell carcinoma (RCC).
  
  LEARNING OBJECTIVES

  • Effectively apply evidence-based research findings and other clinical and biologic factors in the best-practice selection of first-line therapy for patients with metastatic RCC (mRCC).
  • Recall the underlying research database supporting the FDA approval of first-line anti-PD-1/anti-CTLA-4 combination therapy for patients with mRCC, and develop strategies to appropriately integrate this treatment into the care of these individuals.
  • Appraise available clinical trial data evaluating the use of recently FDA-approved anti-PD-1/PD-L1 antibody/multikinase inhibitor combinations for patients with previously untreated mRCC, and counsel individuals with the disease regarding the risks and benefits of these novel regimens.
  • Develop a rational therapeutic approach to the sequencing of systemic therapies for patients with advanced RCC that progresses on first-line treatment, incorporating tyrosine kinase inhibitors, mTOR inhibitors, immunotherapeutic agents and other therapeutic approaches.
  • Recognize side effects and toxicities commonly associated with approved and investigational therapeutic approaches, and use this information to develop supportive care plans for patients with RCC undergoing treatment with these agents and regimens.
  • Recall available and emerging data with other investigational agents and strategies currently in testing for RCC, and where applicable, refer eligible patients for clinical trial participation.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  CME credit is no longer available for this issue
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  This CME activity consists of a video component.
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:
  
  Toni K Choueiri, MD
  Director, Lank Center for Genitourinary Oncology
  Department of Medical Oncology
  Dana-Farber Cancer Institute
  Co-Leader, Kidney Cancer Program
  Dana-Farber/Harvard Cancer Center
  The Jerome and Nancy Kohlberg Professor of Medicine
  Harvard Medical School
  Boston, Massachusetts
  
  Advisory Committee and Consulting Agreements: Alexion Pharmaceuticals, Analysis Group, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, GlaxoSmithKline, Heron Therapeutics, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme; Contracted Research: Alexion Pharmaceuticals, Analysis Group, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Calithera Biosciences, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, Exelixis Inc, F Hoffmann-La Roche Ltd, Foundation Medicine, Genentech, GlaxoSmithKline, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme, Takeda Oncology, TRACON Pharmaceuticals Inc; Honoraria: Alexion Pharmaceuticals, Analysis Group, Apollo Endosurgery Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Corvus Pharmaceuticals, Daré Bioscience, Eisai Inc, EMD Serono Inc, Exelixis Inc, F Hoffmann-La Roche Ltd, Foundation Medicine, Genentech, GlaxoSmithKline, Heron Therapeutics, Ipsen Biopharmaceuticals Inc, Lilly, Merck, Novartis, Peloton Therapeutics Inc, Pfizer Inc, Prometheus Laboratories Inc, Roche Laboratories Inc, Sanofi Genzyme.
  
  Thomas E Hutson, DO, PharmD
  Director, GU Oncology Program
  Co-Director, Urologic Cancer Research and Treatment Center
  Texas Oncology
  Charles A Sammons Cancer Center
  Baylor University Medical Center
  Professor of Medicine
  Texas A&M HSC College of Medicine
  Dallas, Texas
  
  Advisory Committee, Consulting Agreements, Contracted Research and Speakers Bureau: Astellas, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Eisai Inc, EMD Serono Inc, Genentech, Merck, Novartis, Pfizer Inc.
  
  David F McDermott, MD
  Chief, Medical Oncology
  Beth Israel Deaconess Medical Center
  Leader, Kidney Cancer Program
  Dana-Farber/Harvard Cancer Center
  Professor of Medicine
  Harvard Medical School
  Boston, Massachusetts
  
  Consulting Agreements: Alkermes, Bristol-Myers Squibb Company, EMD Serono Inc, Lilly, Merck, Pfizer Inc; Contracted Research: Alkermes, Bristol-Myers Squibb Company, Exelixis Inc, Genentech, Merck, Novartis, Pfizer Inc, X4 Pharmaceuticals Inc.
  
  Thomas Powles, MBBS, MRCP, MD
  Professor of Genitourinary Oncology
  Barts Cancer Institute
  Director of Barts Cancer Centre
  Queen Mary University of London
  London, United Kingdom
  
  Consulting Agreements: Exelixis Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Seattle Genetics.
  
  MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, a member of the Roche Group, Genmab, Genomic Health Inc, Gilead Sciences Inc, GlaxoSmithKline, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  This activity is supported by educational grants from Eisai Inc, Exelixis Inc and Merck.
  
  Hardware/Software Requirements:
  A high-speed Internet connection
  A monitor set to 1280 x 1024 pixels or more
  Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
  Adobe Flash Player 27 plug-in or later
  Adobe Acrobat Reader
  (Optional) Sound card and speakers for audio
  
  Release date: April 2020
  Expiration date: April 2021