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Consensus or Controversy? Clinical Investigators Provide Perspectives on the Current and Future Management of Prostate Cancer
Released May 2019

A special audio program developed from a satellite CME conference held during the 2019 Genitourinary Cancers Symposium featuring expert comments on the application of emerging research to patient care. (Audio Program)

CE Disclosures and Faculty Information

  • TARGET AUDIENCE
    This activity has been designed to meet the educational needs of medical and radiation oncologists, urologists and other allied healthcare professionals involved in the treatment of prostate cancer (PC).

    OVERVIEW OF ACTIVITY
    Cancers of the genitourinary (GU) system affect hundreds of thousands of individuals in the United States each year and account for more than one fourth of all new cancer diagnoses. Of this diverse array of distinct diseases, tumors of the prostate are among the most prevalent and thus the topic of extensive ongoing clinical research. Consequently, the clinical management of both early and more advanced presentations of prostate cancer is constantly evolving, necessitating rapid and consistent access to learning opportunities for clinicians who care for these patients. This CME program was developed from the proceedings of a satellite symposium held during the 2019 Genitourinary Cancers Symposium. It provides the perspectives and experiences of prostate cancer experts to facilitate a better understanding of new management strategies and lingering clinical controversies facing the GU cancer community.

    This activity will help medical oncologists and other allied healthcare professionals to find answers to the individualized questions and concerns they frequently encounter and to in turn provide high-quality cancer care.

    LEARNING OBJECTIVES

    • Appraise the published research database supporting the recent FDA approvals of secondary hormonal agents in the management of nonmetastatic prostate cancer, and consider this information in the discussion of nonresearch treatment options for patients.
    • Explore available data with cytotoxic and secondary hormonal therapy in the setting of hormone-sensitive metastatic prostate cancer to effectively design treatment plans for appropriate patients.
    • Consider patient and disease characteristics in addition to available clinical trial data in the selection and sequencing of available local and systemic treatment modalities for patients with metastatic prostate cancer.
    • Evaluate the rationale for testing for BRCA mutations in patients with metastatic prostate cancer, and advise individuals found to harbor these genetic abnormalities about participation in clinical trials investigating the role of PARP inhibitors.
    • Recall the design of ongoing clinical trials evaluating other novel agents and strategies for prostate cancer, and counsel appropriate patients about availability and participation.

    ACCREDITATION STATEMENT
    This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Penn State College of Medicine and Research To Practice. Penn State College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

    For questions about CME credit, either email continuinged@pennstatehealth.psu.edu or call (717) 531-6483 and reference course number G6435-19-T.

    CREDIT DESIGNATION STATEMENT
    Penn State College of Medicine designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    HOW TO USE THIS CME ACTIVITY
    This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/GUCancers19/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/GUCancers19/Video.

    CONTENT VALIDATION AND DISCLOSURES
    It is the policy of Research To Practice and Penn State College of Medicine to ensure balance, independence, objectivity and scientific rigor in all their educational programs. All faculty, planners and managers participating in this activity are required to disclose any relevant financial relationship(s) they (or spouse/partner) have with a commercial interest that benefits the individual in any financial amount that has occurred within the past 12 months; and the opportunity to affect the content of CME about the products or services of the commercial interest. Research To Practice and Penn State College of Medicine ensured that any conflicts of interest were resolved before the educational activity occurred.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Emmanuel S Antonarakis, MD
    Associate Professor of Oncology and Urology
    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    Baltimore, Maryland

    Advisory Committee and Consulting Agreements: Amgen Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Clovis Oncology, Dendreon Pharmaceuticals Inc, ESSA Pharma Inc, Janssen Biotech Inc, Medivation Inc, a Pfizer Company, Merck, Sanofi Genzyme; Contracted Research: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Dendreon Pharmaceuticals Inc, Genentech, Janssen Biotech Inc, Johnson & Johnson Pharmaceuticals, Merck, Novartis, Sanofi Genzyme, Tokai Pharmaceuticals; Other Remunerated Activities: Co-inventor of a biomarker licensed to QIAGEN.

    A Oliver Sartor, MD
    CE and Bernadine Laborde Professor for Cancer Research
    Medical Director, Tulane Cancer Center
    Assistant Dean for Oncology
    Tulane Medical School
    New Orleans, Louisiana

    Advisory Committee: Bayer HealthCare Pharmaceuticals, EMD Serono Inc, Fusion Pharmaceuticals; Consulting Agreements: Advanced Accelerator Applications, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Blue Earth Diagnostics, Constellation Pharmaceuticals, Dendreon Pharmaceuticals Inc, EMD Serono Inc, Endocyte Inc, Hinova Pharmaceuticals Inc, Johnson & Johnson Pharmaceuticals, Myovant Sciences, Pfizer Inc, Progenics Pharmaceuticals Inc, Sanofi Genzyme; Contracted Research: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Constellation Pharmaceuticals, Dendreon Pharmaceuticals Inc, Endocyte Inc, Innocrin Pharmaceuticals Inc, Invitae, Johnson & Johnson Pharmaceuticals, Merck, Progenics Pharmaceuticals Inc, Roche Laboratories Inc, Sanofi Genzyme, SOTIO LLC; Data and Safety Monitoring Board/Committee: AstraZeneca Pharmaceuticals LP, Johnson & Johnson Pharmaceuticals, Myovant Sciences, Pfizer Inc; Ownership Interest: Lilly.

    Howard I Scher, MD
    D Wayne Calloway Chair in Urologic Oncology
    Co-Chair, Center for Mechanism Based Therapy
    Head, Biomarker Development Initiative
    Member and Attending Physician
    Genitourinary Oncology Service
    Department of Medicine
    Memorial Sloan Kettering Cancer Center
    Professor of Medicine
    Weill Cornell Medical College
    New York, New York

    Board of Directors: Asterias Biotherapeutics; Consulting Agreement: WCG Oncology; Contracted Research: Epic Sciences, Illumina Inc, Innocrin Pharmaceuticals Inc, Janssen Biotech Inc, Menarini Silicon Biosystems, Thermo Fisher Scientific; Uncompensated Consulting: Amgen Inc, ESSA Pharma Inc, Janssen Biotech Inc, Menarini Silicon Biosystems.

    Matthew R Smith, MD, PhD
    Claire and John Bertucci Endowed Chair in Genitourinary Cancers
    Professor of Medicine
    Harvard Medical School
    Director, Genitourinary Malignancies Program
    Massachusetts General Hospital Cancer Center
    Boston, Massachusetts

    Advisory Committee and Consulting Agreements: AbbVie Inc, Amgen Inc, Astellas Pharma Global Development Inc, Bayer HealthCare Pharmaceuticals, Clovis Oncology, Gilead Sciences Inc, Hexal AG, Hinova Pharmaceuticals Inc, Janssen Biotech Inc, Lilly, Novartis, Orion Corporation, Pfizer Inc; Contracted Research: Amgen Inc, Bayer HealthCare Pharmaceuticals, Clovis Oncology, Janssen Biotech Inc, Lilly.

    Cora N Sternberg, MD
    Clinical Director, Englander Institute for Precision Medicine
    Weill Cornell Medicine
    Hematology/Oncology
    New York, New York

    Consulting Agreements: Bayer HealthCare Pharmaceuticals, Pfizer Inc, Sanofi Genzyme; Contracted Research: Bayer HealthCare Pharmaceuticals, Exelixis Inc, Genentech, Janssen Biotech Inc, Medivation Inc, a Pfizer Company, Roche Laboratories Inc, Sanofi Genzyme; Honoraria: Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Janssen Biotech Inc, Sanofi Genzyme.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    PENN STATE COLLEGE OF MEDICINE — Faculty and staff involved in the development and review of this activity have disclosed no relevant financial relationships.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice and Penn State College of Medicine do not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Astellas and Pfizer Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, and Sanofi Genzyme.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: May 2019
    Expiration date: May 2020

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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Consensus or Controversy? Clinical Investigators Provide Perspectives on the Current and Future Management of Prostate Cancer
Released May 2019

A special audio program developed from a satellite CME conference held during the 2019 Genitourinary Cancers Symposium featuring expert comments on the application of emerging research to patient care. (Audio Program)

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