CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This program is intended for medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of lung cancer.
  
  LEARNING OBJECTIVES

  • Acknowledge available clinical trial findings with EGFR tyrosine kinase inhibitors for nonmetastatic EGFR mutation-positive non-small cell lung cancer (NSCLC), and identify patients for whom treatment with this novel approach would be warranted.
  • Counsel patients with newly diagnosed metastatic EGFR mutation-positive NSCLC regarding available therapies, explaining the relevance of mutation type, symptomatology, sites and extent of metastases, prior therapeutic exposure and other factors.
  • Appreciate the biological rationale for dual inhibition of MET and EGFR in patients with EGFR mutation-positive NSCLC, and understand recently presented data establishing the benefit of this strategy.
  • Evaluate the documented efficacy of chemotherapy combined with EGFR-targeted therapy for patients with EGFR mutation-positive metastatic NSCLC, and consider the current role of available approaches in both the front-line and relapsed/refractory settings.
  • Consider the scientific justification for targeting HER3 in patients with EGFR mutation-positive NSCLC, and review the structural components, mechanism of action and available research with novel HER3-directed antibody-drug conjugates (ADCs).
  • Review published research findings with TROP2-directed ADCs for EGFR mutation-positive metastatic NSCLC, and consider the potential clinical role of this strategy.
  • Understand the biology of EGFR exon 20 insertion mutations, and evaluate how currently available therapies should be used in the care of patients with these alterations.
  • Recall the biological rationale for and the design of ongoing clinical trials evaluating novel therapeutic approaches for patients with EGFR mutation-positive NSCLC.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  Audio Program: Research To Practice designates this enduring material for a maximum of 2.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  Video Program: Research To Practice designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  Successful completion of these CME activities, which includes participation in the evaluation component and a post-test, enables the participant to earn up to 2.75 (audio) and 2.25 (video) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  
  Please note, these programs have been specifically designed for the following ABIM specialty: medical oncology.
  
  AMERICAN BOARD OF SURGERY (ABS) — CONTINOUS CERTIFICATION (CC)
  Successful completion of these CME activities, which includes participation in the evaluation component and a post-test, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABS credit.
  
  Please note, these programs have been specifically designed for the following ABS practice area: complex general surgical oncology.
  
  PRIVACY POLICY
  Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.
  
  HOW TO USE THIS CME ACTIVITY
  Audio Program: This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, review the downloadable slide set, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/ASCO2025/EGFRNSCLC/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/ASCO2025/EGFRNSCLC/Video.
  
  Video Program: This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/ASCO2025/EGFRNSCLC/Video/CME. The corresponding audio program is available as an alternative at ResearchToPractice.com/ASCO2025/EGFRNSCLC.
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty reported relevant financial relationships with ineligible entities:
  
  Nicolas Girard, MD, PhD
  Head of Medical Oncology, Institut Curie
  Full Professor
  UVSQ, Paris-Saclay University
  Paris, France
  
  Advisory Committees: AbbVie Inc, Amgen Inc, AstraZeneca Pharmaceuticals LP, Baxter International Inc, Bristol Myers Squibb, Daiichi Sankyo Inc, Gilead Sciences Inc, Janssen Biotech Inc, LEO Pharma, Lilly, MSD, Pfizer Inc, Pierre Fabre, Sanofi, Suven Pharma, Takeda Pharmaceutical Company Limited; Contracted Research (Through Institution): AstraZeneca Pharmaceuticals LP, MSD; Data and Safety Monitoring Boards/Committees: Roche Laboratories Inc; Speakers Bureaus: AbbVie Inc, Amgen Inc, AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Daiichi Sankyo Inc, Janssen Biotech Inc, MSD, Sanofi; Nonrelevant Financial Relationships: Clinical Care Options, PeerVoice.
  
  Jonathan Goldman, MD
  Professor of Medicine, UCLA Hematology and Oncology
  Director of Clinical Trials in Thoracic Oncology
  Associate Director of Drug Development
  UCLA Health
  Santa Monica, California
  
  Consulting Agreements: AbbVie Inc, Amgen Inc, AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Genentech, a member of the Roche Group, Janssen Biotech Inc, Lilly, Pfizer Inc, Summit Therapeutics; Contracted Research: AbbVie Inc, Agenus Inc, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Genentech, a member of the Roche Group, GSK, Janssen Biotech Inc, Lilly, Merck, Pfizer Inc, Puma Biotechnology Inc, RayzeBio Inc, Summit Therapeutics, Tango Therapeutics.
  
  Pasi A Jänne, MD, PhD, FASCO
  Senior Vice President for Translational Medicine
  Lowe Center for Thoracic Oncology
  Professor of Medicine
  Harvard Medical School
  David M Livingston, MD, Chair
  Director, Robert and Renée Belfer Center for Applied Cancer Science
  Director, Chen-Huang Center for EGFR-Mutant Lung Cancers
  Dana-Farber Cancer Institute
  Boston, Massachusetts
  
  Advisory Committees: AbbVie Inc, Accutar Biotechnology Inc, Allorion Therapeutics, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biocartis, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Chugai Pharmaceutical Co Ltd, Daiichi Sankyo Inc, Dizal Pharma, Duality Biologics, Eisai Inc, Frontier Medicines, Genentech, a member of the Roche Group, GSK, Hongyun Biotechnology, Lilly, Merus, Mirati Therapeutics Inc, Monte Rosa Therapeutics, Myris Therapeutics, Novartis, Nuvalent, Pfizer Inc, Roivant, Sanofi, Scorpion Therapeutics, SFJ Pharmaceuticals, Syndax Pharmaceuticals, Takeda Pharmaceuticals USA Inc, TOLREMO, Transcenta, Voronoi; Contracted Research (All to Institution): AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc, Daiichi Sankyo Inc, Lilly, Puma Biotechnology Inc, Revolution Medicines, Takeda Pharmaceuticals USA Inc; Royalties: Postmarketing royalties from Dana-Farber Cancer Institute-owned intellectual property on EGFR mutations licensed to Labcorp; Stock Options — Private Company: Frontier Medicines.
  
  Suresh S Ramalingam, MD
  Executive Director, Winship Cancer Institute
  Roberto C Goizueta Chair for Cancer Research
  Emory University School of Medicine
  Atlanta, Georgia
  
  Contracted Research (Research Support to Institution): Amgen Inc, AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Merck, Pfizer Inc; Data and Safety Monitoring Boards/Committees: Gilead Sciences Inc, Johnson & Johnson (no honorarium received).
  
  Joshua K Sabari, MD
  Attending Physician
  Thoracic Medical Oncology
  Assistant Professor of Medicine
  NYU Langone Health
  Perlmutter Cancer Center
  New York, New York
  
  Advisory Committees and Consulting Agreements (Advisory Boards/Consultant, Personal Fees): AbbVie Inc, AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, EMD Serono Inc, Genentech, a member of the Roche Group, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Mirati Therapeutics Inc, Pfizer Inc, Regeneron Pharmaceuticals Inc, Revolution Medicines, Sanofi, Takeda Pharmaceuticals USA Inc; Contracted Research (Institutional): Bristol Myers Squibb, Janssen Biotech Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Mirati Therapeutics Inc, Regeneron Pharmaceuticals Inc.
  
  MODERATOR
  Helena Yu, MD
  Medical Oncologist
  Associate Attending
  Memorial Sloan Kettering Cancer Center
  New York, New York
  
  Consulting Agreements: AbbVie Inc, Amgen Inc, AstraZeneca Pharmaceuticals LP, Black Diamond Therapeutics Inc, Bristol Myers Squibb, Cullinan Therapeutics, Daiichi Sankyo Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, Pfizer Inc, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc; Contracted Research (To Institution): AstraZeneca Pharmaceuticals LP, Black Diamond Therapeutics Inc, Cullinan Therapeutics, Daiichi Sankyo Inc, Janssen Biotech Inc, Kumquat Biosciences, SystImmune Inc, Taiho Oncology Inc; Data and Safety Monitoring Boards/Committees: Janssen Biotech Inc, Mythic Therapeutics.
  
  SURVEY PARTICIPANTS
  Shirish M Gadgeel, MD — Advisory Committees: AbbVie Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Lilly, Merck, Nuvation Bio, Pfizer Inc, Takeda Pharmaceuticals USA Inc; Data and Safety Monitoring Boards/Committees: AstraZeneca Pharmaceuticals LP. Alexander I Spira, MD, PhD — Advisory Committees: Amgen Inc, ArriVent Biopharma, AstraZeneca Pharmaceuticals LP, Black Diamond Therapeutics Inc, Blueprint Medicines, Bristol Myers Squibb, Daiichi Sankyo Inc, Gritstone bio, Incyte Corporation, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Lilly, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Novartis, Regeneron Pharmaceuticals Inc, Sanofi, Takeda Pharmaceuticals USA Inc; Contracted Research: AbbVie Inc, ADC Therapeutics, AI Therapeutics, Alkermes, Amgen Inc, ArriVent Biopharma, Astellas, Astex Pharmaceuticals, AstraZeneca Pharmaceuticals LP, Black Diamond Therapeutics Inc, Blueprint Medicines, BluPrint Oncology, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, CytomX Therapeutics, Daiichi Sankyo Inc, Gritstone bio, Ignyta Inc, Incyte Corporation, Janssen Biotech Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, MacroGenics Inc, Medikine, Mersana Therapeutics Inc, Nalo Therapeutics, Novartis, Plexxikon Inc, Prelude Therapeutics, Regeneron Pharmaceuticals Inc, Revolution Medicines, Roche Laboratories Inc, Rubius Therapeutics, Scorpion Therapeutics, Synthekine, Takeda Pharmaceuticals USA Inc; Honoraria: AbbVie Inc, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, CytomX Therapeutics, Janssen Biotech Inc, Merck, Novartis, Prelude Therapeutics, Takeda Pharmaceuticals USA Inc.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  These activities are supported by educational grants from AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Johnson & Johnson, and Taiho Oncology Inc.
  
  Release date: June 2025
  Expiration date: June 2026
  
  After completing the post-test, learners may download and review the answers here in order to identify further areas of study.