Would you offer an Oncotype DX assay for an otherwise healthy 75-year-old patient with a Grade II, MSS T3 (1 out of 20 nodes positive) tumor?
If not, what adjuvant systemic therapy would you likely recommend for this patient?
Would you offer an Oncotype DX assay for an otherwise healthy 60-year-old patient with a Grade II, MSS T4N0 (0 out of 20 nodes positive) tumor?
If not, what adjuvant systemic therapy would you likely recommend for this patient?
Would you offer an Oncotype DX® assay for an otherwise healthy 60-year-old patient with a Grade II, microsatellite stable (MSS) T3N0 (0 out of 20 nodes positive) tumor?
If not, what adjuvant systemic therapy would you likely recommend for this patient?
Would you offer an Oncotype DX assay for an otherwise healthy 75-year-old patient with a Grade II, MSS T3 (1 out of 20 nodes positive) tumor?
If not, what adjuvant systemic therapy would you likely recommend for this patient?
Would you offer an Oncotype DX assay for an otherwise healthy 60-year-old patient with a Grade II, microsatellite stable (MSS) T3N0 (0 out of 20 nodes positive) tumor?
If not, what adjuvant systemic therapy would you likely recommend for this patient?
OVERVIEW OF ACTIVITY
The recommended dose and schedule of obinutuzumab for the approved regimen with chlorambucil in CLL is:
Cycle 1: 100 mg intravenously on day 1, 900 mg on day 2 and 1,000 mg on days 8 and 15
Cycles 2-6: 1,000 mg administered intravenously every 28 days
The recommended dose and schedule of rituximab for the approved regimen with fludarabine and cyclophosphamide (FC) in CLL is:
375 mg/m2 the day prior to the initiation of FC chemotherapy, then 500 mg/m2 on day 1 of cycles 2-6 (every 28 days)
OVERVIEW OF ACTIVITY