CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This program is intended for urologists, medical and radiation oncologists and other allied healthcare professionals involved in the treatment of prostate cancer.
  
  LEARNING OBJECTIVES

  • Appreciate the incidence and clinical relevance of PTEN deficiency in prostate cancer, and understand the optimal method for assessing PTEN status in patients.
  • Evaluate emerging Phase III data with combined AKT and androgen biosynthesis inhibition for patients with metastatic hormone-sensitive prostate cancer and PTEN deficiency, and consider the potential role of this form of therapy in the current treatment algorithm.
  • Implement a plan of care to recognize and manage side effects and toxicities associated with AKT inhibitors in preparation for their potential availability for patients with prostate cancer.
  • Recall the design of ongoing clinical trials evaluating novel AKT inhibitors in combination with standard therapies for metastatic prostate cancer, and appropriately counsel patients about availability and participation.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  Audio Program: Research To Practice designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  Video Program: Research To Practice designates this enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  Successful completion of these CME activities, which includes participation in the evaluation component and a post-test, enables the participant to earn up to 2.25 (audio) and 1.75 (video) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  
  Please note, these programs have been specifically designed for the following ABIM specialty: medical oncology.
  
  AMERICAN BOARD OF SURGERY (ABS) — CONTINUOUS CERTIFICATION (CC)
  Successful completion of these CME activities, which includes participation in the evaluation component and a post-test, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABS credit.
  
  Please note, these programs have been specifically designed for the following ABS practice area: complex general surgical oncology.
  
  PRIVACY POLICY
  Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.
  
  HOW TO USE THIS CME ACTIVITY
  Audio Program: This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, review the downloadable slide set, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/AUA2025/AKTiProstate/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/AUA2025/AKTiProstate/Video.
  
  Video Program: This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/AUA2025/AKTiProstate/Video/CME. The corresponding audio program is available as an alternative at ResearchToPractice.com/AUA2025/AKTiProstate.
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty reported relevant financial relationships with ineligible entities:
  
  Leonard G Gomella, MD
  The Bernard W Godwin Professor of Prostate Cancer
  Chairman, Department of Urology
  Senior Director, Clinical Affairs, Sidney Kimmel Cancer Center
  Enterprise VP for Urology, Jefferson Health
  Editor-in-Chief, Canadian Journal of Urology International
  Thomas Jefferson University
  Philadelphia, Pennsylvania
  
  Advisory Committees: AstraZeneca Pharmaceuticals LP, Ferring Pharmaceuticals, Lantheus, Merck; Patents: Through Thomas Jefferson University.
  
  Evan Y Yu, MD
  Section Head, Medical Oncology, Clinical Research Division
  Fred Hutchinson Cancer Center
  Medical Director, Clinical Research Support
  Fred Hutchinson Cancer Research Consortium
  Professor of Medicine
  Division of Hematology and Oncology, Department of Medicine
  University of Washington School of Medicine
  Seattle, Washington
  
  Advisory Committees: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, Johnson & Johnson Pharmaceuticals, Lantheus, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Oncternal Therapeutics, Tolmar; Contracted Research: Bayer HealthCare Pharmaceuticals, Blue Earth Diagnostics, Dendreon Pharmaceuticals Inc, Lantheus, Merck, Oncternal Therapeutics, Seagen Inc, Tyra Biosciences Inc.
  
  MODERATOR
  Daniel George, MD
  Eleanor Easley Distinguished Chair
  Professor of Medicine, Surgery and Urology
  Duke University School of Medicine
  ACS Research Professor
  Co-Lead, DCI Center for Prostate and Urologic Cancers
  Duke Cancer Institute
  Durham, North Carolina
  
  Advisory Committees: Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Cardinal Health, Novartis, Pfizer Inc; Consulting Agreements: Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, Exelixis Inc, Johnson & Johnson Pharmaceuticals, Merck, Novartis; Contracted Research: AstraZeneca Pharmaceuticals LP, Bristol Myers Squibb, Corvus Pharmaceuticals, Exelixis Inc, Merck, Novartis, Pfizer Inc; Data and Safety Monitoring Boards/Committees: AstraZeneca Pharmaceuticals LP; Nonrelevant Financial Relationships: IDEOlogy Health, MJH Life Sciences, Targeted Oncology, UpToDate, UroToday.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.
  
  These activities are supported by an educational grant from AstraZeneca Pharmaceuticals LP.
  
  Release date: May 2025
  Expiration date: May 2026
  
  After completing the post-test, learners may download and review the answers here in order to identify further areas of study.