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Oncology Investigators Provide Perspectives on the Prevention and Management of Tumor Lysis Syndrome (Video Program)
Released November 2017

Featuring interviews with Drs William G Wierda and Amit Lahoti. (Video Program)

CE Disclosures and Faculty Information

    This activity is intended for medical oncologists, hematology-oncology fellows, physician assistants and other allied healthcare professionals involved in the treatment of hematologic cancers.

    Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the rapid onset of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia and/or acute renal failure. Despite the relatively rare incidence of TLS, the clinical landscape of this syndrome changed dramatically with the April 11, 2016 FDA approval of the Bcl-2 inhibitor venetoclax for relapsed/refractory chronic lymphocytic leukemia (CLL) harboring the del(17p) chromosomal abnormality. Given the availability of venetoclax and emerging evidence of its antitumor activity in non-del(17p) CLL and other cancer types, it is likely that concern over TLS will greatly increase in general oncology practice. To bridge the gap between research and patient care, this program uses one-on-one discussions with leading oncology and nephrology investigators to help overcome clinician uncertainties and alleviate current practice gaps surrounding the prevention and management of this potentially devastating complication of effective cancer treatment.


    • Understand the pathophysiology of TLS, recognize its disease- and treatment-related risk factors and establish an evidence-based approach for the prevention and management of this oncologic emergency.
    • Identify patients at increased risk for TLS or its complications (eg, those with increased baseline uric acid, the elderly, those with renal or cardiac dysfunction), and institute appropriate treatment modifications, including early intervention with rasburicase.
    • Formulate an approach to manage TLS-associated metabolic abnormalities — hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia and concomitant renal insufficiency — including recognition of when nephrology consultation is warranted.
    • Appraise the risk-benefit profiles of chemoimmunotherapy treatments and targeted agents and regimens for CLL, and develop management strategies for the unique toxicities associated with recently approved therapeutics.
    • Recognize the increased risk of TLS in patients with CLL treated with venetoclax, and implement approaches to ensure that appropriate administration protocols are followed to mitigate the risk of this potentially fatal toxicity.

    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CME credit is no longer available for this issue

    CME credit is no longer available for this issue

    This CME activity consists of a video component.
    CME credit is no longer available for this issue

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    William G Wierda, MD, PhD
    DB Lane Cancer Research Distinguished Professor
    Department of Leukemia
    Division of Cancer Medicine
    The University of Texas MD Anderson Cancer Center
    Houston, Texas

    Consulting Agreement: Sanofi Genzyme; Contracted Research: Genentech BioOncology, Gilead Sciences Inc, GlaxoSmithKline, Pharmacyclics LLC, an AbbVie Company.

    Amit Lahoti, MD
    Associate Professor
    Department of Nephrology
    Division of Internal Medicine
    The University of Texas MD Anderson Cancer Center
    Assistant Professor
    Department of Internal Medicine
    Baylor College of Medicine
    Instructor, Division of Internal Medicine
    The University of Texas Medical School at Houston
    Houston, Texas

    No relevant conflicts of interests to disclose.

    EDITOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Baxalta Inc, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, CTI BioPharma Corp, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Medivation Inc, a Pfizer Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, NanoString Technologies, Natera Inc, Novartis, Novocure, Onyx Pharmaceuticals, an Amgen subsidiary, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seattle Genetics, Sigma-Tau Pharmaceuticals Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro Inc, Teva Oncology and Tokai Pharmaceuticals Inc.

    RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.

    This activity is supported by an educational grant from AbbVie Inc.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: November 2017
    Expiration date: November 2018

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Watch videos
(WIFI is recommended for best performance):

Interview with William G Wierda, MD, PhD

Interview with Amit Lahoti, MD

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