This activity has been designed to meet the educational needs of medical and radiation oncologists, urologists and other allied healthcare professionals.
OVERVIEW OF ACTIVITY
The past several years have seen an explosion in the emergence of new potential therapies that leverage the natural ability of the human body to attack and treat cancer. Known as immune-mediated therapies or cancer immunotherapies, these promising treatments are taking center stage at medical conferences and generating excitement all over the world. Although they may be diverse in terms of their biology and current clinical management, genitourinary (GU) cancers — prostate cancer, renal cell carcinoma (RCC), bladder cancer, et cetera — are unified in their potential as fertile ground for immunologic therapy and research and have been at the forefront of both past and current efforts in this regard. Not surprisingly, with the many exciting advances rapidly occurring both within the field of GU tumors and elsewhere, a number of vexing questions and clinical challenges are emerging simultaneously.
These video proceedings from a CME symposium held during the 2015 Genitourinary Cancers Symposium feature discussions with leading investigators in the management of prostate, renal and bladder cancer regarding actual patient cases and related clinical research findings. By providing information on important immunotherapeutic developments, this activity will assist medical and radiation oncologists, urologists and other healthcare professionals to address existing management uncertainties and determine the current role and future potential of immunotherapeutic interventions in patients with common GU cancers.
LEARNING OBJECTIVES
- Develop a basic understanding of the human immune response, and identify the underlying mechanisms by which various tumor types evade this process to proliferate and grow.
- Analyze the biologic basis for various immunotherapeutic strategies designed to boost an individual’s immune response to combat cancer.
- Effectively apply evidence-based research findings to appropriately integrate available immunotherapeutics into the management of advanced prostate cancer and RCC.
- Compare and contrast the mechanisms of action, efficacy and safety/toxicity of approved and investigational immunotherapies for the treatment of prostate cancer, RCC, bladder cancer and other GU tumors to determine the current and/or potential utility of each in clinical practice.
- Appraise the rationale for and clinical data with investigational anti-PD-1 and anti-PD-L1 antibodies in patients with metastatic RCC and bladder cancer.
- Recognize immune-related adverse events and other common side effects associated with approved and developmental immunotherapeutics in order to offer supportive management strategies.
- Recall the design of ongoing clinical trials evaluating novel immunotherapeutic approaches, and counsel appropriately selected patients with GU cancers about availability and participation.
ACCREDITATION STATEMENT
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CME credit is no longer available for this issue
CREDIT DESIGNATION STATEMENT
CME credit is no longer available for this issue
HOW TO USE THIS CME ACTIVITY
This CME activity contains an audio component.
CME credit is no longer available for this issue
CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a
conflict of interest resolution process:
Charles G Drake, MD, PhD
Co-Director
Multi-D Prostate Cancer Clinic
Associate Professor
Oncology, Urology and Immunology
Johns Hopkins Sidney Kimmel Cancer Center
Baltimore, Maryland
Consulting Agreements: Amplimmune Inc, Bristol-Myers Squibb Company, Compugen, Dendreon Corporation, Eisai Inc, Genentech BioOncology, ImmuneXcite Inc, ImmuNext Inc, Novartis Pharmaceuticals Corporation, Potenza Therapeutics, Roche Laboratories Inc, Sanofi; Patents: Amplimmune Inc, Bristol-Myers Squibb Company, Potenza Therapeutics; Stock Ownership: Compugen, ImmuneXcite Inc, ImmuNext Inc.
David F McDermott, MD
Associate Professor of Medicine
Harvard Medical School
Director, Biologic Therapy and Cutaneous Oncology Programs
Beth Israel Deaconess Medical Center
Leader, Kidney Cancer Program
Dana-Farber Harvard Cancer Center
Boston, Massachusetts
Advisory Committee: Pfizer Inc; Consulting Agreements: Bristol-Myers Squibb Company, Genentech BioOncology, Merck, Roche Laboratories Inc; Contracted Research: Novartis Pharmaceuticals Corporation.
Daniel P Petrylak, MD
Professor of Medicine
Director, Prostate and GU Medical Oncology
Co-Director
Signal Transduction Program
Yale Cancer Center
New Haven, Connecticut
Consulting Agreements: Bayer HealthCare Pharmaceuticals, Bellicum Pharmaceuticals Inc, Dendreon Corporation, Ferring Pharmaceuticals, Johnson & Johnson Pharmaceuticals, Medivation Inc, Pfizer Inc, Sanofi, Takeda Oncology; Contracted Research: Celgene Corporation, Sanofi, Takeda Oncology; Grant Support: Dendreon Corporation, Johnson & Johnson Pharmaceuticals, OncoGenex Pharmaceuticals Inc, Progenics Pharmaceuticals Inc.
David I Quinn, MBBS, PhD
Medical Director, Norris Cancer Hospital and Clinics
Head, GU Cancer Section
Division of Cancer Medicine and Blood Diseases
USC/Norris Comprehensive Cancer Center
Los Angeles, California
Advisory Committee: Astellas Scientific and Medical Affairs Inc, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Dendreon Corporation, Genentech BioOncology, Janssen Biotech Inc, Medivation Inc, Novartis Pharmaceuticals Corporation, Pfizer Inc, Roche Laboratories Inc, Sanofi; Consulting Agreements: Astellas Scientific and Medical Affairs Inc, Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Dendreon Corporation, Genentech BioOncology, Janssen Biotech Inc, Medivation Inc, Novartis Pharmaceuticals Corporation, Pfizer Inc, Roche Laboratories Inc; Other Remunerated Activities: Medivation Inc.
Nicholas J Vogelzang, MD
Executive Medical Director
US Oncology Research
Associate Chair, Genitourinary and Developmental Therapeutics Programs
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada
Consulting Agreements: Amgen Inc, Aveo Pharmaceuticals, BIND Biosciences Inc, Janssen Biotech Inc; Contracted Research: GlaxoSmithKline, Pfizer Inc; Honoraria: AbbVie Inc, Bavarian Nordic, DAVA Oncology, Endocyte Inc, Mannkind Corporation, UpToDate Inc; Paid Research: Endocyte Inc, Exelixis Inc, GlaxoSmithKline, PAREXEL International Corporation, Progenics Pharmaceuticals Inc, US Oncology Inc, Viamet Pharmaceuticals Inc; Paid Travel: Bayer HealthCare Pharmaceuticals, Celgene Corporation, Dendreon Corporation, Exelixis Inc, Genentech BioOncology, Novartis Pharmaceuticals Corporation, Pfizer Inc, Roche Laboratories Inc, US Oncology Inc; Speakers Bureau: Bayer HealthCare Pharmaceuticals, Caris Life Sciences Ltd, Dendreon Corporation, GlaxoSmithKline, Medivation Inc, Sanofi, Takeda Oncology; Stock Ownership: Caris Life Sciences Ltd.
MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Amgen Inc, Astellas Scientific and Medical Affairs Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Lilly, Medivation Inc, Merck, Myriad Genetic Laboratories Inc, NanoString Technologies, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals, an Amgen subsidiary, Pharmacyclics Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Sigma-Tau Pharmaceuticals Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Teva Oncology, Tokai Pharmaceuticals Inc and VisionGate Inc.
RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.
This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Dendreon Corporation, Genentech BioOncology and Prometheus Laboratories Inc.
Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
Adobe Flash Player 10.2 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio
Last review date: July 2015
Expiration date: July 2016