ASCOGINonCRC14 | Research To Practice

Submitted by Anonymous on Mon, 04/07/2014 - 12:31

TARGET AUDIENCE
This activity is intended for medical oncologists, surgeons and other healthcare providers involved in the treatment of gastrointestinal cancers.

OVERVIEW OF ACTIVITY
Local and systemic treatment approaches for noncolorectal (non-CRC) GI cancers are continuously evolving. Novel molecular-targeted and biologic therapies have changed best-practice care in some instances (eg, gastric cancer, hepatocellular carcinoma, GI stromal tumors), and late-stage clinical trials have demonstrated evidence of exciting results for additional novel agents that are poised for integration into existing treatment algorithms. Thus, in addition to maintaining a sound understanding of the conventional but distinct treatment algorithms applicable to each subtype of non-CRC GI cancer, practicing oncologists must now rationally integrate targeted agents into their individualized therapeutic recommendations for the safe and effective clinical management of diseases they seldom encounter.

By providing information on the latest research developments and their potential application to routine practice, this activity is designed to assist medical oncologists, surgeons and other healthcare providers with the formulation of up-to-date clinical management strategies for various non-CRC GI cancers.

LEARNING OBJECTIVES

Upon completion of this activity, participants should be able to:

Apply the results of emerging clinical research to the best-practice management of non-CRC GI cancers.
Use clinical and molecular biomarkers to select optimal treatment strategies for patients with locally advanced or metastatic gastric or gastroesophageal cancer.
Communicate the benefits and risks of existing and emerging local and systemic interventions to patients with locally advanced or metastatic hepatocellular cancer.
Assess available and emerging research information to guide treatment decision-making for patients with metastatic GI stromal tumors.
Recall new data with investigational agents demonstrating promising activity in non-CRC GI cancers.
Counsel patients with non-CRC GI cancers about participation in ongoing clinical trials.

ACCREDITATION STATEMENT

CME credit is no longer available for this issue

CREDIT DESIGNATION STATEMENT

CME credit is no longer available for this issue

HOW TO USE THIS CME ACTIVITY
This CME activity consists of a video component. The participant should watch the video.

CME credit is no longer available for this issue

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:

Charles S Fuchs, MD, MPH
Director, Center for Gastrointestinal Cancer
Dana-Farber/Harvard Cancer Center
Professor of Medicine
Harvard Medical School
Boston, Massachusetts

Advisory Committee: Celgene Corporation, Genentech BioOncology, Lilly, Metamark Genetics Inc, Sanofi, Takeda Pharmaceuticals North America Inc; Consulting Agreements: ImClone Systems, a wholly owned subsidiary of Eli Lilly and Company, Lilly.

Pamela L Kunz, MD
Assistant Professor of Medicine
Division of Oncology
Stanford University School of Medicine
Stanford, California

Advisory Committee and Stock Ownership: Guardant Health Inc; Contracted Research: Advanced Accelerator Applications, Genentech BioOncology, Lexicon Pharmaceuticals Inc, Merck, Sanofi.

J Randolph Hecht, MD
Professor of Clinical Medicine
Carol and Saul Rosenzweig Chair in
Cancer Therapies Development
Director, UCLA GI Oncology Program
Santa Monica, California

No real or apparent conflicts of interest to disclose.

Johanna C Bendell, MD
Director, GI Oncology Research
Associate Director, Drug Development Unit
Sarah Cannon Research Institute
Nashville, Tennessee

No real or apparent conflicts of interest to disclose.

Alan P Venook, MD
Professor of Clinical Medicine
University of California, San Francisco
San Francisco, California

Advisory Committee: Bayer HealthCare Pharmaceuticals; Consulting Agreements: Bayer HealthCare Pharmaceuticals, Sanofi; Contracted Research: Bayer HealthCare Pharmaceuticals, Bristol-Myers Squibb Company, Genentech BioOncology, GlaxoSmithKline, Lilly, Onyx Pharmaceuticals Inc.

MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Algeta US, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, Exelixis Inc, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Lilly, Medivation Inc, Merck, Millennium: The Takeda Oncology Company, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc, Teva Oncology and VisionGate Inc.

RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

This activity is supported by educational grants from Bayer HealthCare Pharmaceuticals, Genentech BioOncology, Genomic Health Inc, Incyte Corporation, Lilly, Regeneron Pharmaceuticals and Sanofi.

Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
Adobe Flash Player 10.2 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio

Last review date: April 2014
Expiration date: April 2015