TARGET AUDIENCE
This activity has been designed to meet the educational needs of medical oncologists, hematologist-oncologists, radiation oncologists, fellows and other healthcare providers involved in the treatment of lung cancer.

OVERVIEW OF ACTIVITY
Lung cancer is increasingly being recognized as a heterogeneous group of tumors. Not long ago, it was clinically sufficient to make a differentiation between small cell lung cancer and non-small cell lung cancer (NSCLC). Today, individualized treatment decisions are increasingly driven by genetic biomarkers in addition to histological subtype and patient-specific characteristics.

Determining which treatment approach is most appropriate in a given case requires careful consideration of patient and disease characteristics as well as available health system resources. To facilitate appropriate decision-making for the various presentations of NSCLC, oncology clinicians must be kept abreast of key research developments related to this rapidly evolving field. This CME program uses a roundtable discussion with leading lung cancer clinical investigators to assist practicing clinicians in this regard and ensure they are delivering state-of-the-art care.

LEARNING OBJECTIVES

• Identify distinct subtypes of adenocarcinoma of the lung — including those with EGFR mutations, EML4-ALK gene fusions, MET amplification and other recently identified driver mutations — and the approved and investigational treatment options for patients with these mutations.
• Assess new oncogenic pathways mediating the growth of unique NSCLC tumor subsets, and recall emerging data with experimental agents exploiting these targets.
• Apply the results of existing and emerging clinical research to the multimodality treatment of Stage II and III NSCLC.
• Develop an evidence-based approach to the selection of induction and maintenance biologic therapy and/or chemotherapy for patients with advanced NSCLC.
• Describe emerging data on the efficacy and safety of tumor immunotherapy directed at the PD-1/PD-L1 pathway in lung cancer, and consider this information when counseling patients regarding clinical trial participation.

ACCREDITATION STATEMENT

CME credit is no longer available for this issue

CREDIT DESIGNATION STATEMENT

CME credit is no longer available for this issue

HOW TO USE THIS CME ACTIVITY
This CME activity consists of a video component. The participant should watch the video.

CME credit is no longer available for this issue

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:

Chandra P Belani, MD
Miriam Beckner Distinguished Professor of Medicine
Penn State College of Medicine
Deputy Director
Penn State Hershey Cancer Institute
Hershey, Pennsylvania

Consulting Agreements: Genentech BioOncology, Lilly.

Ramaswamy Govindan, MD
Professor of Medicine
Co-Director, Section of Medical Oncology
Division of Oncology
Washington University School of Medicine
St Louis, Missouri

Consulting Agreements: Abbott Laboratories, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Covidien, Mallinckrodt Pharmaceuticals, Merck, Pfizer Inc, Roche Laboratories Inc.

John V Heymach, MD, PhD
Professor and Chair
Thoracic/Head and Neck Medical Oncology
The University of Texas
MD Anderson Cancer Center
Houston, Texas

Advisory Committee: Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Genentech BioOncology, GlaxoSmithKline, Pfizer Inc; Consulting Agreement: OSI Oncology; Contracted Research: Bayer HealthCare Pharmaceuticals, GlaxoSmithKline, ImClone Systems, a wholly owned subsidiary of Eli Lilly and Company, Lilly, Pfizer Inc.

Gregory J Riely, MD, PhD
Assistant Attending
Memorial Sloan-Kettering Cancer Center
Assistant Professor
Weill Cornell Medical College
New York, New York

Consulting Agreement: ARIAD Pharmaceuticals Inc; Contracted Research: Astellas, Bristol-Myers Squibb Company, Chugai Pharmaceutical Co Ltd, GlaxoSmithKline, Infinity Pharmaceuticals Inc, Novartis Pharmaceuticals Corporation, Pfizer Inc.

Mark A Socinski, MD
Professor of Medicine and Thoracic Surgery
Director, Lung Cancer Section
Division of Hematology/Oncology
Co-Director, UPMC Lung Cancer Center of Excellence
Co-Director, Lung and Thoracic Malignancies Program
University of Pittsburgh
UPMC Cancer Pavilion
Pittsburgh, Pennsylvania

Contracted Research: Celgene Corporation, Genentech BioOncology, GlaxoSmithKline, Lilly, Pfizer Inc, Synta Pharmaceuticals Corp; Data and Safety Monitoring Board: Abbott Laboratories; Speakers Bureau: Celgene Corporation, Genentech BioOncology, Lilly.

David R Spigel, MD
Program Director, Lung Cancer Research
Sarah Cannon Research Institute
Nashville, Tennessee

Advisory Committee: Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Genentech BioOncology, Lilly, Novartis Pharmaceuticals Corporation, Pfizer Inc, Sanofi.

MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Algeta US, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, Exelixis Inc, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Lilly, Medivation Inc, Merck, Millennium: The Takeda Oncology Company, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc, Teva Oncology and VisionGate Inc.

RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

This activity is supported by educational grants from Astellas, Biodesix Inc, Genentech BioOncology, Lilly and Novartis Pharmaceuticals Corporation.

Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
Adobe Flash Player 10.2 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio

Last review date: March 2014
Expiration date: March 2015