RTP Mobile Logo
Second Opinion: Clinical Investigators Provide Their Perspectives on Challenging Cases and Controversies in the Management of Multiple Myeloma
Released December 2013

Featuring perspectives from Dr Sagar Lonial. (Video Program)

CE Disclosures and Faculty Information

  • TARGET AUDIENCE
    This activity is intended for hematologists, medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of multiple myeloma (MM).

    OVERVIEW OF ACTIVITY
    It is estimated that approximately 148,040 new lymphoid and myeloid cancer cases will be identified in the United States in the year 2012, and 65,900 individuals will die from these diseases. Importantly, there are currently over 45 drug products labeled for use in the management of hematologic malignancies, comprising more than 55 distinct FDA-approved indications. While this extensive list of available treatment options is reassuring for patients and oncology healthcare professionals, it poses quite a challenge to the practicing clinician who must maintain up-to-date knowledge of appropriate clinical management strategies across a vast spectrum of liquid and solid tumors.

    These proceedings from a case-based CME symposium combine the perspectives of 5 renowned investigators on a number of controversial issues in the diagnosis and treatment of MM with a review of emerging research information in this area to assist medical oncologists, hematology-oncology fellows and other healthcare providers as they attempt to formulate optimal disease management strategies in the face of a constantly evolving body of knowledge.

    LEARNING OBJECTIVES

    • Integrate the results of emerging clinical research into the selection of optimal systemic therapy for patients with MM who are eligible and ineligible for stem cell transplant.
    • Use biomarkers to assess risk for patients with MM, and recommend systemic treatment commensurate with prognosis and likelihood of therapeutic response.
    • Compare and contrast patient outcomes with lenalidomide- and bortezomib-based induction therapy, and consider the role of combined immunomodulatory and proteasome inhibitor regimens.
    • Communicate the benefits and risks of postinduction maintenance therapy to appropriately selected patients with MM.
    • Recognize treatment-associated side effects, and offer patients acceptable alternative dosing/administration and/or supportive management interventions to address them.
    • Evaluate the safety profiles and response outcomes observed in studies of next-generation proteasome inhibitors and immunomodulatory agents for patients with MM.
    • Counsel appropriately selected patients with MM about participation in ongoing clinical trials investigating novel therapeutic agents and strategies.

    ACCREDITATION STATEMENT
    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.


    CME credit is no longer available for this issue

    CREDIT DESIGNATION STATEMENT

    CME credit is no longer available for this issue

    HOW TO USE THIS CME ACTIVITY
    This CME activity consists of a video component. The participant should watch the video.


    CME credit is no longer available for this issue

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Rafael Fonseca, MD
    Getz Family Professor of Cancer
    Chair, Department of Internal Medicine
    Mayo Clinic Arizona
    Scottsdale, Arizona

    Consulting Agreements: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, Genzyme Corporation, Intellikine, Lilly, Medtronic Inc, Millennium: The Takeda Oncology Company, Otsuka Pharmaceutical Co Ltd; Research Support: Celgene Corporation, Onyx Pharmaceuticals Inc.

    Sagar Lonial, MD
    Professor
    Vice Chair of Clinical Affairs
    Director of Translational Research, B-Cell Malignancy Program
    Department of Hematology and Medical Oncology
    Winship Cancer Institute
    Emory University School of Medicine
    Atlanta, Georgia

    Advisory Committee and Consulting Agreements: Bristol-Myers Squibb Company, Celgene Corporation, Lilly, Millennium: The Takeda Oncology Company, Novartis Pharmaceuticals Corporation, Onyx Pharmaceuticals Inc, Sanofi.

    Paul G Richardson, MD
    Associate Professor of Medicine
    Harvard Medical School
    Clinical Director of the Jerome Lipper Multiple Myeloma Center
    Dana-Farber Cancer Institute
    Boston, Massachusetts

    Advisory Committee: Bristol-Myers Squibb Company, Celgene Corporation, Millennium: The Takeda Oncology Company, Novartis Pharmaceuticals Corporation.

    A Keith Stewart, MBChB
    Dean for Research, Mayo Clinic in Arizona
    Consultant, Division of Hematology/Oncology
    Vasek and Anna Maria Polak
    Professorship in Cancer Research
    Scottsdale, Arizona

    Advisory Committee: Amgen Inc, Celgene Corporation; Consulting Agreements: Celgene Corporation, Millennium: The Takeda Oncology Company; Contracted Research: Millennium: The Takeda Oncology Company, Onyx Pharmaceuticals Inc.

    Ravi Vij, MD
    Associate Professor of Medicine
    Washington University School of Medicine
    Section of Stem Cell Transplant and Leukemia Division of Medical Oncology St Louis, Missouri

    Consulting Agreements: Abbott Laboratories, Bristol-Myers Squibb Company, Celgene Corporation, Onyx Pharmaceuticals Inc; Contracted Research: Celgene Corporation, Onyx Pharmaceuticals Inc; Speakers Bureau: Celgene Corporation, Cephalon Inc, Millennium: The Takeda Oncology Company, Onyx Pharmaceuticals Inc.

    EDITORDr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Algeta US, Allos Therapeutics, Amgen Inc, ArQule Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine Inc, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Lilly, Medivation Inc, Merck, Millennium: The Takeda Oncology Company, Mundipharma International Limited, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc and Teva Oncology.

    RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Millennium: The Takeda Oncology Company and Onyx Pharmaceuticals Inc.

    Hardware/Software Requirements:
    A high-speed Internet connection  
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
    Adobe Flash Player 10.2 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: December 2013
    Expiration date: December 2014

Acknowledge and close

Watch video
(WIFI is recommended for best performance):

A case-based Grand Rounds presentation featuring perspectives from Dr Sagar Lonial.
28:17 minutes