TARGET AUDIENCE
This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of lung cancer.

OVERVIEW OF ACTIVITY
Lung cancer is a devastating disease with broad-reaching impact on public health as it accounts for 15% of all new cancer cases in the United States and the most cancer-related deaths among both men and women. In the year 2013, it is estimated that 228,190 individuals will be diagnosed and 159,480 individuals will die from the disease. Chemotherapy has been the mainstay systemic therapeutic intervention in lung cancer, and the number of available cytotoxic chemotherapies exhibiting activity has increased substantially over the past several years. Development of new therapeutic strategies beyond chemotherapy has been the focus of extensive recent research, and the result has been the availability of several therapies demonstrating some degree of activity in subsets of non-small cell lung cancer (NSCLC) with unique tolerability profiles that are distinct from those of traditional chemotherapeutics. The advent of these next-generation targeted treatments presents new promise of both efficacy and enhanced safety for patients but also challenges clinicians who must integrate such therapies into standard treatment algorithms. Oncology nurses play an integral role in the successful delivery of systemic anticancer therapy and in the maintenance of patient physical and psychosocial well-being.

These video proceedings from the fourth part of a 6-part integrated CNE curriculum originally held at the 2013 ONS Annual Congress feature discussions with leading lung cancer investigators and their nursing counterparts regarding actual patient cases and recent clinical research findings affecting the optimal therapeutic and supportive care for each patient scenario. By providing information on the latest research developments in the context of expert perspectives, this CNE activity will assist oncology nurses, nurse practitioners and clinical nurse specialists with the formulation of state-of-the-art clinical management strategies to facilitate optimal care of patients with lung cancer.

LEARNING OBJECTIVES

• Discuss the benefits and risks associated with systemic treatments used in the evidence-based treatment of metastatic NSCLC, including chemotherapeutic agents and targeted biologic therapies.
• Communicate the clinical relevance of gene mutations and tumor histology to patients with NSCLC.
• Explain the relative risk of treatment-induced side effects to patients with NSCLC who are eligible to receive chemotherapy and bevacizumab.
• Educate patients receiving EGFR inhibitors about preventive and emergent strategies to reduce or ameliorate dermatotoxicity.
• Identify opportunities to enhance the collaborative role of oncology nurses in the comprehensive biopsychosocial care of patients with advanced NSCLC to improve clinical and quality-of-life outcomes.
• Recall ongoing trials of investigational approaches and treatment strategies in NSCLC, and consent and refer patients for study participation.

ACCREDITATION STATEMENT
Research To Practice is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

CME credit is no longer available for this issue

CREDIT DESIGNATION STATEMENT

CME credit is no longer available for this issue

HOW TO USE THIS CNE ACTIVITY

This CNE activity consists of a video component. The participant should watch the video.

CME credit is no longer available for this issue

CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CNE activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:

Ann Culkin, RN, OCN
Clinical Nurse
Thoracic Oncology Service
Memorial Sloan-Kettering Cancer Center
New York, New York

No real or apparent conflicts of interest to report.

Beth Eaby-Sandy, MSN, CRNP, OCN
Nurse Practitioner
Outpatient Thoracic Oncology
Abramson Cancer Center
University of Pennsylvania
Philadelphia, Pennsylvania

Consulting Agreements: Amgen Inc, Boehringer Ingelheim Pharmaceuticals Inc, Genentech BioOncology; Speakers Bureau: Amgen Inc, Genentech BioOncology, Lilly USA LLC.

Rogerio C Lilenbaum, MD
Chief Medical Officer
Smilow Cancer Hospital
Professor of Medicine
Yale University School of Medicine
New Haven, Connecticut

Consulting Agreement: Genentech BioOncology.

Lecia V Sequist, MD, MPH
Associate Professor of Medicine
Harvard Medical School
Center for Thoracic Cancers
Massachusetts General Hospital Cancer Center
Boston, Massachusetts

Advisory Committee: AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim
Pharmaceuticals Inc, Clovis Oncology, GlaxoSmithKline, Merrimack Pharmaceuticals.

MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME/CNE activities from the following commercial interests: AbbVie Inc, Algeta US, Allos Therapeutics, Amgen Inc, ArQule Inc, Astellas, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, EMD Serono Inc, Foundation Medicine Inc, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Lilly USA LLC, Medivation Inc, Merck, Millennium: The Takeda Oncology Company, Mundipharma International Limited, Novartis Pharmaceuticals Corporation, Onyx Pharmaceuticals Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc and Teva Oncology.

RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.

This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

This activity is supported by educational grants from Astellas, Boehringer Ingelheim Pharmaceuticals Inc, Celgene Corporation and Genentech BioOncology.

Hardware/Software Requirements:
A high-speed Internet connection  
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
Adobe Flash Player 10.2 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio

There is no implied or real endorsement of any product by RTP or the American Nurses Credentialing Center.