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Dermatologic Oncology Update, Issue 2, 2012
Released October 2012

Featuring interviews with Dr Paul B Chapman and Prof Dirk Schadendorf. (Audio Content)

CE Disclosures and Faculty Information

    Taken together, melanoma and nonmelanoma skin cancer — basal cell and cutaneous squamous cell cancer (BCC and SCC) — likely represent the most prevalent form of human cancer. Fortunately, the vast majority of skin cancers present as minimally invasive BCC and SCC and, as such, are highly curable with local treatment alone. However, in rare instances these characteristically indolent lesions progress and necessitate systemic intervention with the support of limited randomized clinical evidence. In contrast, cancerous melanoma is the most aggressive form of skin cancer with a predilection toward distant metastases, even when identified in the clinically early stages of disease. Thus melanoma and nonmelanoma skin cancer are distinct entities, each posing unique challenges to the oncology community. Featuring information on the latest research developments along with expert perspectives, this CME activity is designed to assist medical oncologists and hematology-oncology fellows with the formulation of up-to-date clinical management strategies.
    • Integrate practice-changing clinical trial results into the evidence-based treatment algorithm for front-line and subsequent management of advanced melanoma.
    • Develop a treatment algorithm for BRAF V600 mutation-positive and wild-type advanced melanoma.
    • Compare and contrast the patterns of tumor response resulting from melanoma treatment with cytotoxic agents versus kinase inhibitors versus immunoregulatory agents.
    • Recognize immune-related adverse events associated with anti-CTLA-4 antibody therapy, and offer supportive management strategies to minimize and/or manage these side effects.
    • Investigate the evolving role of anti-PD-1 in advanced solid tumors.
    • Evaluate the potential clinical and research implications of recent Phase III trial results evaluating the combination of MEK and BRAF inhibitors in the treatment of melanoma.
    • Identify patients with locally advanced or metastatic BCC for whom hedgehog inhibitor therapy may be an appropriate treatment option.
    • Counsel appropriately selected patients about participation in ongoing clinical trials.
    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
    Research To Practice designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
    This CME activity contains an audio component. To receive credit, the participant should review the CME information, listen to the audio MP3s, complete the Post-test with a score of 75% or better and fill out the Educational Assessment and Credit Form located on our website at ResearchToPractice.com/DOU212/CME.

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
    FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process: Dr ChapmanAdvisory Committee, Consulting Agreements and Paid Research: Bristol-Myers Squibb Company, Genentech BioOncology, GlaxoSmithKline, Roche Laboratories Inc. Prof SchadendorfAdvisory Committee: Amgen Inc, Bristol-Myers Squibb Company, GlaxoSmithKline, Novartis Pharmaceuticals Corporation, Roche Laboratories Inc; Consulting Agreements: Amgen Inc, GlaxoSmithKline; Speakers Bureau: Bristol-Myers Squibb Company, Roche Laboratories Inc.
    EDITORDr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: Abbott Laboratories, Allos Therapeutics, Amgen Inc, ArQule Inc, Astellas, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals/Onyx Pharmaceuticals Inc, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, EMD Serono Inc, Foundation Medicine Inc, Genentech BioOncology, Genomic Health Inc, ImClone Systems, a wholly owned subsidiary of Eli Lilly and Company, Incyte Corporation, Lilly USA LLC, Medivation Inc, Millennium: The Takeda Oncology Company, Mundipharma International Limited, Novartis Pharmaceuticals Corporation, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc and Teva.

    RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.
    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Celgene Corporation and Genentech BioOncology.

    Hardware/Software Requirements:

    A high-speed Internet connection  
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
    Adobe Flash Player 10.2 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: October 2012
    Expiration date: October 2013

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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Dermatologic Oncology Update, Issue 2, 2012
Released October 2012

Featuring interviews with Dr Paul B Chapman and Prof Dirk Schadendorf. (Audio Content)

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