CE Disclosures and Faculty Information

• TARGET AUDIENCE
  
  This activity is intended for medical oncologists, radiation oncologists, GI surgeons and other allied professionals involved in the treatment of colorectal cancer (CRC).
  
  OVERVIEW OF ACTIVITY
  
  Representing one of the most common conditions encountered in medical oncology today, cancer of the colon and rectum is the third most frequently diagnosed cancer and the third most common cause of death among all neoplasms in both men and women in the United States. To assist clinicians with making management decisions for this often-encountered disease, several consensus- and evidence-based treatment guidelines have been developed. Yet despite the existence of these tools, many areas of controversy persist within academic and community settings. These video proceedings from an interactive Grand Rounds activity combine the perspectives of 5 CRC investigators on a number of controversial issues in the diagnosis and treatment of CRC with a review of emerging research information in this area to assist medical oncologists and other allied cancer professionals with the formulation of up-to-date clinical management strategies.
  
  LEARNING OBJECTIVES

  • Employ case-based interactive learning to effectively adopt evidence-based diagnostic and therapeutic approaches for patients with CRC.
  • Appropriately integrate biomarkers and multigene assays when communicating prognosis and treatment options to patients with early-stage colon cancer.
  • Incorporate the most recent evidence regarding molecular markers in optimizing therapeutic decisions for patients with advanced CRC.
  • Apply clinical research data to optimize the use of anti-VEGF- and anti-EGFR-based therapy in the treatment of advanced CRC.
  • Compare and contrast the efficacy and safety of perioperative and postoperative systemic therapy for patients presenting with resectable or borderline resectable CRC hepatic metastases.
  • Develop an evidence-based approach regarding the use of neoadjuvant chemoradiation therapy for patients with locally advanced rectal cancer.
  • Counsel appropriately selected patients with CRC about participation in ongoing clinical trials investigating novel therapeutic agents and strategies.

  ACCREDITATION STATEMENT
  
  CME credit is no longer available for this issue
  
  CREDIT DESIGNATION STATEMENT
  
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  
  This CME activity consists of a video component. The participant should watch the video.
  
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:
  
  Cathy Eng, MD
  Associate Professor
  Associate Medical Director, Colorectal Center
  Department of Gastrointestinal Medical Oncology
  The University of Texas MD Anderson Cancer Center
  Houston, Texas
  
  Advisory Committee: Genentech, A Member of the Roche Group; Data and Safety Monitoring Board: GlaxoSmithKline.
  
  Axel Grothey, MD
  Professor of Oncology
  Department of Medical Oncology
  Mayo Clinic
  Rochester, Minnesota
  
  Paid Research: Bayer HealthCare Pharmaceuticals, Daiichi Sankyo Inc, Genentech BioOncology.
  
  Howard S Hochster, MD
  Associate Director (Clinical Research)
  Yale Cancer Center
  Professor of Medicine
  Yale School of Medicine
  New Haven, Connecticut
  
  Advisory Committee: Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Daiichi Sankyo Inc, Genentech BioOncology, Genomic Health Inc, GlaxoSmithKline, Myriad Genetics Inc, Sanofi; Consulting Agreements: Amgen Inc, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Genentech BioOncology, Genomic Health Inc, Sanofi; Speakers Bureau: Genomic Health Inc.
  
  John L Marshall, MD
  Chief, Hematology and Oncology
  Director, Ruesch Center for the Cure of GI Cancers
  Lombardi Comprehensive Cancer Center
  Georgetown University
  Washington, DC
  
  Advisory Committee: Amgen Inc, Boehringer Ingelheim Pharmaceuticals Inc, Genentech BioOncology; Data and Safety Monitoring Board: Daiichi Sankyo Inc; Paid Research and Speakers Bureau: Amgen Inc, Genentech BioOncology.
  
  Alan P Venook, MD
  Professor of Clinical Medicine
  University of California, San Francisco
  San Francisco, California
  
  Advisory Committee: Myriad Genetics Inc; Paid Research: Bayer HealthCare Pharmaceuticals, Genentech BioOncology, GlaxoSmithKline.
  
  RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.
  
  This activity is supported by an educational grant from Genentech BioOncology.
  
  Hardware/Software Requirements:
  An Internet connection that is at least 28.8 Kbps
  A monitor set to 1280 x 1024 pixels or more
  Netscape 7.x or newer, Internet Explorer 5.x or newer, or Firefox
  Macromedia Flash plug-in 6.0 or greater
  Adobe Acrobat Reader
  (Optional) Sound card and speakers for audio
  
  Last review date: July 2012
  Expiration date: July 2013