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Lung Cancer Update, Issue 1, 2010
Released March 2010

Featuring interviews with Drs Corey J Langer, Alice Shaw, Suresh Ramalingam and George R Simon. (Text and Audio Content)

CE Disclosures and Faculty Information

  • OVERVIEW OF ACTIVITY

    Lung cancer is the leading cause of cancer mortality in the United States for both men and women, resulting in more deaths than breast, prostate, colon and pancreatic cancer combined. Progress in the screening, prevention and treatment of this disease has been limited, and approximately 85 percent of patients who develop lung cancer will die from it. Traditional chemotherapy, surgery and radiation therapy have had a modest effect on long-term outcomes. However, the advent of biologic agents in lung cancer has led to recent improvements in disease-free and overall survival in select patient populations. Published results from ongoing and completed studies lead to the continual emergence of novel therapeutic strategies and changes in the indications for existing treatments. In order to offer optimal patient care — including the option of clinical trial participation — the practicing clinician must be well informed of these advances. Featuring information on the latest research developments along with expert perspectives, this CME program is designed to assist medical oncologists and radiation oncologists with the formulation of up-to-date clinical management strategies for the care of patients with lung cancer.

    LEARNING OBJECTIVES

    • Identify distinct subtypes of adenocarcinoma of the lung, including those with EGFR mutations and EML4-ALK gene fusions, and the investigational and treatment options for these patients.
    • Describe mechanisms of acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) and emerging data on irreversible EGFR TKIs.
    • Summarize clinical trial data on the treatment of extensive small cell lung cancer.
    • Appraise the outcomes of molecular analysis-directed individualized therapy (MADeIT) for advanced NSCLC.
    • Formulate individualized treatment plans addressing the first-line and maintenance management of recurrent or progressive non-small cell lung cancer, considering unique patient and tumor characteristics.
    • Effectively utilize tumor histology and biomarkers in making evidence-based lung cancer treatment decisions.
    • Counsel appropriately selected patients with lung cancer about participation in ongoing clinical trials.

    ACCREDITATION STATEMENT

    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CME credit is no longer available for this issue

    CREDIT DESIGNATION STATEMENT

    CME credit is no longer available for this issue


    HOW TO USE THIS CME ACTIVITY

    This CME activity contains both audio and print components. The participant should listen to the audio MP3s and read the text portion. The text portion of this activity contains edited comments, clinical trial schemas, graphics and references that supplement the audio MP3s, as well as links to relevant full-text articles, abstracts, trial information and other web resources.

    CONTENT VALIDATION AND DISCLOSURES

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process: Dr LangerAdvisory Committee: Abbott Laboratories, Abraxis BioScience, Amgen Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix, Bristol-Myers Squibb Company, Caris Diagnostics Inc, Clarient Inc, Genentech BioOncology, ImClone Systems Incorporated, Lilly USA LLC, Morphotek Inc, Novartis Pharmaceuticals Corporation, Onyx Pharmaceuticals Inc, Pfizer Inc, Sanofi-Aventis; Paid Research: Bristol-Myers Squibb Company, Genentech BioOncology, ImClone Systems Incorporated, Lilly USA LLC, OSI Oncology, Pfizer Inc; Speakers Bureau: Bristol-Myers Squibb Company, Genentech BioOncology, ImClone Systems Incorporated, Lilly USA LLC, OSI Oncology. Dr ShawAdvisory Committee: Pfizer Inc. Dr RamalingamAdvisory Committee: Amgen Inc, Genentech BioOncology, GlaxoSmithKline, ImClone Systems Incorporated, Lilly USA LLC, Roche Laboratories Inc. Dr SimonAdvisory Committee: Lilly USA LLC; Consulting Agreements: Genentech BioOncology, Lilly USA LLC; Speakers Bureau: Lilly USA LLC.

    EDITORDr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: Abraxis BioScience, Amgen Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals/Onyx Pharmaceuticals Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Centocor Ortho Biotech Services LLC, Cephalon Inc, Eisai Inc, EMD Serono Inc, Genentech BioOncology, Genomic Health Inc, Genzyme Corporation, GlaxoSmithKline, ImClone Systems Incorporated, Lilly USA LLC, Millennium Pharmaceuticals Inc, Monogram BioSciences Inc, Novartis Pharmaceuticals Corporation, OSI Oncology, Roche Laboratories Inc, Sanofi-Aventis and Spectrum Pharmaceuticals Inc.

    RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This program is supported by educational grants from Abraxis BioScience, AstraZeneca Pharmaceuticals LP, Boehringer Ingelheim Pharmaceuticals Inc and Genentech BioOncology/OSI Oncology.

    Hardware/Software Requirements:
    An Internet connection that is at least 28.8 Kbps
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 6.x or newer, Firefox 2.x or newer, or Safari 2.x or newer
    Macromedia Flash plug-in 6.0 or greater
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: March 2010
    Expiration date: March 2011

Acknowledge and close

Lung Cancer Update, Issue 1, 2010
Released March 2010

Featuring interviews with Drs Corey J Langer, Alice Shaw, Suresh Ramalingam and George R Simon. (Text and Audio Content)