Submitted by nenadkesic@gmail.com on Tue, 11/07/2017 - 08:33

OVERVIEW OF ACTIVITY
Tumor lysis syndrome (TLS) is an oncologic emergency characterized by the rapid onset of hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia and/or acute renal failure. Despite the relatively rare incidence of TLS, the clinical landscape of this syndrome changed dramatically with the April 11, 2016 FDA approval of the Bcl-2 inhibitor venetoclax for relapsed/refractory chronic lymphocytic leukemia (CLL) harboring the del(17p) chromosomal abnormality. Given the availability of venetoclax and emerging evidence of its antitumor activity in non-del(17p) CLL and other cancer types, it is likely that concern over TLS will greatly increase in general oncology practice. To bridge the gap between research and patient care, this program uses one-on-one discussions with leading oncology and nephrology investigators to help overcome clinician uncertainties and alleviate current practice gaps surrounding the prevention and management of this potentially devastating complication of effective cancer treatment.

LEARNING OBJECTIVES