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Data + Perspectives: Clinical Investigators Explore the Current and Future Management of Triple-Negative Breast Cancer
Released February 2020

Proceedings from a satellite symposium during the 42nd annual San Antonio Breast Cancer Symposium. Featuring perspectives from Dr Erika Hamilton, Prof Sherene Loi, Dr Mark E Robson and Dr Hope S Rugo. (Video Program)

CE Information and Faculty Disclosures

    This activity is intended for medical oncologists, breast surgeons, radiation oncologists and other healthcare professionals involved in the diagnosis and treatment of breast cancer (BC).

    Several relevant clinical and regulatory developments coupled with many lingering practical management concerns and the activation of a multitude of clinical trials evaluating novel agents have challenged physicians and their support staffs as they attempt to deliver state-of-the-art care for patients with triple-negative BC.

    These video proceedings from a CME symposium during the San Antonio Breast Cancer Symposium feature discussions with leading researchers with an expertise in BC regarding actual cases from their practices and the published data that drive clinical decision-making for patients in those and diverse other situations. By providing information on the latest research developments and their potential application to routine practice, this activity is designed to assist medical oncologists and other healthcare professionals with the formulation of up-to-date clinical management strategies.


    • Evaluate published research findings, relevant clinical factors (eg, age, performance status, prior therapeutic exposure) and patient preferences in the selection and sequencing of available therapeutic agents for metastatic ER/PR-negative, HER2-negative BC.
    • Appreciate the biologic rationale for, available data with and potential long-term benefits of anti-PD-1/PD-L1 antibody therapy for patients with metastatic triple-negative BC (mTNBC).
    • Consider data supporting the FDA approval of anti-PD-L1 antibody therapy combined with chemotherapy for newly diagnosed PD-L1-positive mTNBC, and use this information to identify patients who may be appropriate for this approach in clinical practice.
    • Assess the biologic rationale for ongoing clinical trials evaluating anti-PD-1/PD-L1 antibodies alone or in combination with other systemic therapies for TNBC in order to effectively communicate to patients the potential benefits of trial participation.
    • Appraise published efficacy and safety data with the use of PARP inhibitors for mTNBC harboring a BRCA1/2 mutation, and consider the diagnostic and therapeutic implications of these findings for nonresearch clinical care.
    • Appreciate the mechanisms of action of, early data with and ongoing research efforts evaluating other novel agents and treatment strategies under development for patients with TNBC.

    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CME credit is no longer available for this issue

    CME credit is no longer available for this issue

    This CME activity consists of a video component.
    CME credit is no longer available for this issue

    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Erika Hamilton, MD
    Director, Breast and Gynecologic Research Program
    Sarah Cannon Research Institute
    Nashville, Tennessee

    Consulting Agreements: AstraZeneca Pharmaceuticals LP, Black Diamond Therapeutics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Daiichi Sankyo Inc, Genentech, Lilly, Mersana Therapeutics, Novartis, Pfizer Inc, Puma Biotechnology Inc, Roche Laboratories Inc, Silverback Therapeutics; Contracted Research: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Aravive Inc, ArQule Inc, Arvinas, AstraZeneca Pharmaceuticals LP, BerGenBio ASA, Black Diamond Therapeutics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Clovis Oncology, Curis Inc, CytomX Therapeutics, Daiichi Sankyo Inc, Deciphera Pharmaceuticals, eFFECTOR Therapeutics Inc, Eisai Inc, EMD Serono Inc, Fochon Pharmaceuticals Ltd, Fosun Orinove PharmaTech Inc, FUJIFILM Pharmaceuticals USA Inc, Genentech, H3 Biomedicine, Harpoon Therapeutics, Hutchison MediPharma, Immunomedics Inc, InventisBio, Leap Therapeutics Inc, Lilly, Lycera, MacroGenics Inc, Marker Therapeutics Inc, Medivation Inc, a Pfizer Company, Mersana Therapeutics, Merus BV, Molecular Templates, Novartis, NuCana, OncoMed Pharmaceuticals Inc, Pfizer Inc, Radius Health Inc, Regeneron Pharmaceuticals Inc, Rgenix, Roche Laboratories Inc, Seattle Genetics, Sermonix Pharmaceuticals, Silverback Therapeutics, Stemcentrx, Sutro Biopharma, Syndax Pharmaceuticals Inc, Syros Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Torque Therapeutics, Unum Therapeutics, Verastem Inc, Zenith Epigenetics Ltd, Zymeworks.

    Professor Sherene Loi, MBBS, PhD
    Medical Oncologist, Breast Unit
    Lab Head
    Head, Breast Cancer Clinical Trials Unit
    National Breast Cancer Foundation of Australia Endowed Chair
    Peter MacCallum Cancer Centre
    Melbourne, Australia

    Consulting Agreements: Aduro Biotech, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Genentech, Merck, Novartis, Pfizer Inc, Roche Laboratories Inc, Seattle Genetics; Contracted Research: Bristol-Myers Squibb Company, Genentech, Lilly, Merck, Novartis, Pfizer Inc, Puma Biotechnology Inc, Roche Laboratories Inc.

    Mark E Robson, MD
    Chief, Breast Medicine Service
    Attending Physician, Breast Medicine and Clinical Genetics Services
    Member, Memorial Sloan Kettering Cancer Center
    Professor of Medicine, Weill Cornell Medical College
    New York, New York

    Advisory Committee and Consulting Agreements: AstraZeneca Pharmaceuticals LP, McKesson; Contracted Research: AbbVie Inc, AstraZeneca Pharmaceuticals LP, Invitae, Medivation Inc, a Pfizer Company, Myriad Genetic Laboratories Inc, Tesaro, A GSK Company; Other Advisory Role: Daiichi Sankyo Inc, Merck, Pfizer Inc.

    Hope S Rugo, MD
    Professor of Medicine
    Director, Breast Oncology and Clinical Trials Education
    University of California, San Francisco Medical Center
    UCSF Helen Diller Family Comprehensive Cancer Center
    San Francisco, California

    Contracted Research: Daiichi Sankyo Inc, Eisai Inc, Genentech, Immunomedics Inc, Lilly, MacroGenics Inc, Merck, Novartis, OBI Pharma Inc, Odonate Therapeutics, Pfizer Inc, Seattle Genetics; Paid Travel: Amgen Inc, AstraZeneca Pharmaceuticals LP, Lilly, MacroGenics Inc, Merck, Mylan NV, Pfizer Inc, Puma Biotechnology Inc.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Eisai Inc, Genentech and Merck.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: February 2020
    Expiration date: February 2021

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Watch videos
(WIFI is recommended for best performance):


Established Management Paradigms for Advanced Triple-Negative Breast Cancer (TNBC); Actionable and Other Potentially Relevant Biomarkers to Inform Decision-Making

Immune Checkpoint Inhibition as a Rational Therapeutic Strategy for Advanced TNBC

Available Data with and Practical Integration of PARP Inhibition into the Care of Patients with mTNBC

Novel Applications of Immune Checkpoint Inhibitors Alone or in Combination with Other Agents for Patients with Early and Advanced TNBC; Other Promising Agents in Late-Stage Clinical Trials

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