CE Disclosures and Faculty Information

• TARGET AUDIENCE
  This activity is intended for medical oncologists, hematologists-oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of Waldenström macroglobulinemia (WM).
  
  OVERVIEW OF ACTIVITY
  WM is a rare, incurable hematologic disorder characterized by infiltration of the bone marrow and often extramedullary sites by a lymphoplasmacytic infiltrate and an immunoglobulin M (IgM) monoclonal gammopathy. Despite the usually indolent course of WM, a significant proportion of patients require treatment because of hypersecretion of IgM and the invasion of bone marrow and peripheral organs by neoplastic lymphoplasmacytic lymphoma cells. Historically a dearth of research and therapeutic advancements has persisted in the field, but a recent increase in dedicated research to better explain the pathobiology of WM has identified several clinical and genetic markers that serve to prognosticate disease course and patient outcomes. This work has led to dedicated clinical trials and the development of novel drugs and regimens, including the first FDA-approved agent for this diagnosis, ibrutinib monotherapy. The rapid emergence of treatment options, and the unique toxicities and practical nuances associated with their use, has complicated traditional therapeutic decision-making. Although several consensus- and evidence-based treatment guidelines are available to assist clinicians with making management recommendations in this dynamic clinical and research environment, the rarity of the disease means that community oncologists are likely to have limited experience caring for patients with WM.
  
  To bridge the gap between research and patient care, this program features a joint discussion with 2 leading hematology-oncology clinical investigators. By providing access to the latest scientific developments and the perspectives of experts in the field, this CME activity will assist medical oncologists with the formulation of up-to-date clinical management strategies.
  
  LEARNING OBJECTIVES

  • Understand the criteria for diagnosis and initiation of therapy for patients with WM, and use this information to guide initial workup and treatment decision-making.
  • Recall published efficacy and safety data supporting the recent FDA approval of ibrutinib/rituximab for patients with untreated WM, and use this information to identify individuals for whom this combination may be appropriate.
  • Appreciate the frequency and significance of the molecular biomarkers MYD88 L265P and CXCR4, and determine how this information should be used to guide protocol and nonresearch decision-making for patients with newly diagnosed and relapsed/refractory WM.
  • Formulate an evidence-based approach to the sequence and selection of therapy for patients with progressive WM, considering age and performance status, symptomatology, prior therapeutic exposure and other disease-related factors.
  • Assess emerging research data on the efficacy of proteasome inhibitors, Bcl-2 inhibitors and CXCR4 antagonists in the management of WM.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  Audio Program: Research To Practice designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits^™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  Video Program: Research To Practice designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits^™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  Successful completion of these CME activities, which includes participation in the evaluation components, enables the participant to earn up to 1.5 (audio) and 1.5 (video) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
  
  Please note, these programs have been specifically designed for the following ABIM specialties: medical oncology and hematology.
  
  Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.
  
  HOW TO USE THIS CME ACTIVITY
  Audio Program: This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/OncologyTodayWM19/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/OncologyTodayWM19/Video.
  
  Video Program: This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the Post-test with a score of 80% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/OncologyTodayWM19/Video/CME. The corresponding audio program is available as an alternative at ResearchToPractice.com/OncologyTodayWM19.
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:
  
  Meletios A Dimopoulos, MD
  Department of Medical Therapeutics
  School of Medicine
  National and Kapodistrian University of Athens
  Athens, Greece
  
  Honoraria: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, Janssen Biotech Inc, Takeda Oncology.
  
  Steven P Treon, MD, PhD
  Professor, Harvard Medical School
  Lead Physician, Dana-Farber Cancer Institute
  Director, Bing Center for Waldenström’s Macroglobulinemia
  Boston, Massachusetts
  
  Consulting Agreement: Janssen Biotech Inc.
  
  MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  This activity is supported by educational grants from AbbVie Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, and Pharmacyclics LLC, an AbbVie Company.
  
  Hardware/Software Requirements:
  A high-speed Internet connection
  A monitor set to 1280 x 1024 pixels or more
  Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
  Adobe Flash Player 27 plug-in or later
  Adobe Acrobat Reader
  (Optional) Sound card and speakers for audio
  
  Release date: July 2019
  Expiration date: July 2020
  
  

  After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.