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Oncology Today with Dr Neil Love: Thyroid Cancer — Issue 2 (Video Presentation)
Released October 2021

Featuring perspectives from Dr Marcia S Brose. Published October 4, 2021. (Video Presentation)

CE Disclosures and Faculty Information

  • TARGET AUDIENCE
    This activity is intended for medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of thyroid cancer.

    LEARNING OBJECTIVES

    • Appraise the efficacy and safety of multitargeted tyrosine kinase inhibitors for radioactive iodine (RAI)-refractory advanced thyroid cancer, and discern how these agents can be optimally employed in patient care.
    • Evaluate patient- and disease-related factors to appropriately select and sequence available therapeutic options for RAI-refractory thyroid cancer.
    • Recognize the spectrum and prevalence of potentially targetable genomic alterations in patients with thyroid cancer, and discuss the means by which these alterations contribute to tumor growth and proliferation.
    • Recall FDA-approved and guideline-endorsed diagnostic platforms for biomarker testing in patients with advanced thyroid cancer, and refine clinical testing algorithms by assessing the advantages and disadvantages of available assays.
    • Analyze available safety and efficacy research results with novel RET inhibitors for patients with RET-driven thyroid cancer, and appropriately integrate these agents into treatment algorithms.
    • Recall other validated biomarkers of response to targeted treatment for advanced thyroid cancer (eg, NTRK fusions), and counsel patients harboring these abnormalities about personalized therapeutic recommendations.
    • Use the results of genomic analyses to integrate available and emerging novel targeted therapies into treatment decision-making for patients with thyroid cancer.

    ACCREDITATION STATEMENT
    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CREDIT DESIGNATION STATEMENT
    Audio Program: Research To Practice designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Video Program: Research To Practice designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
    Successful completion of these CME activities, which includes participation in the evaluation components and short post-tests, enables the participant to earn up to 1 (audio) and 0.75 (video) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Please note, these programs have been specifically designed for the following ABIM specialty: medical oncology.

    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    HOW TO USE THIS CME ACTIVITY
    Audio Program: This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, complete the Post-test with a score of 100% and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/OncologyTodayThyroid21/Issue2/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/OncologyTodayThyroid21/Issue2/Video.

    Video Program: This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the Post-test with a score of 100% and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/OncologyTodayThyroid21/Issue2/Video/CME. The corresponding audio program is available as an alternative at ResearchToPractice.com/OncologyTodayThyroid21/Issue2.

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

    Marcia S Brose, MD, PhD
    Vice Chair of Hematology/Oncology
    Sidney Kimmel Cancer Center Division Director
    Jefferson Health Northeast
    Co-Director, Community-Based Clinical Research
    Sidney Kimmel Cancer Center
    Jefferson University
    Philadelphia, Pennsylvania

    Advisory Committee: Blueprint Medicines, Exelixis Inc, Lilly; Consulting Agreements: Bayer HealthCare Pharmaceuticals, Eisai Inc, Exelixis Inc, Lilly; Contracted Research: Bayer HealthCare Pharmaceuticals, Blueprint Medicines, Exelixis Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company.

    EDITOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: AbbVie Inc, Adaptive Biotechnologies Corporation, ADC Therapeutics, Agios Pharmaceuticals Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Coherus BioSciences, Daiichi Sankyo Inc, Eisai Inc, Epizyme Inc, Exact Sciences Inc, Exelixis Inc, Five Prime Therapeutics Inc, Foundation Medicine, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Genmab, Gilead Sciences Inc, GlaxoSmithKline, Grail Inc, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Novartis, Novocure Inc, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seagen Inc, Servier Pharmaceuticals LLC, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, Tesaro, A GSK Company, TG Therapeutics Inc, Turning Point Therapeutics Inc and Verastem Inc.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Blueprint Medicines, Exelixis Inc, Genentech, a member of the Roche Group, and Lilly.

    Release date: October 2021
    Expiration date: October 2022

    After completing the Post-test, learners may download and review the answers here in order to identify further areas of study.

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