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Submitted by web@researchtop... on Mon, 08/03/2020 - 12:57

 

Topic 1: Biomarker analysis for patients with colorectal cancer (CRC)
Topic 2: Effect of tumor sidedness on prognosis and response to therapy
Topic 3: Sequencing of systemic therapy for patients with metastatic CRC (mCRC); selection of patients for therapy with EGFR antibodies
Topic 4: Role of BRAF mutations and the recently FDA-approved combination of encorafenib and cetuximab for patients with mCRC with a BRAF V600E mutation
Topic 5: Response to BRAF-targeted therapies in patients with BRAF V600E mutations
Topic 6: Ongoing investigation of mechanisms of resistance to BRAF-targeted therapies
Topic 7: Efficacy of immune checkpoint inhibitors pembrolizumab, nivolumab and nivolumab/ipilimumab in patients with mCRC; effect of MSI status on response to immunotherapy
Topic 8: Effect of POLE mutations and tumor mutation burden (TMB) on response to checkpoint inhibitors; recent approval of pembrolizumab for patients with unresectable or metastatic TMB-high (≥10 mut/Mb) solid tumors
Topic 9: Potential role of immune checkpoint inhibitors in patients with mCRC who have microsatellite-stable disease
Topic 10: Integration of TAS-102 and regorafenib in the management of mCRC
Topic 11: Dosing considerations and tolerability of regorafenib; association of tumor cavitation and response to regorafenib
Topic 12: Sequencing of TAS-102 and regorafenib in mCRC
Topic 13: Response to the combination of regorafenib and nivolumab among patients with mCRC
Topic 14: Targeting HER2 in mCRC; activity and side-effect profile of trastuzumab deruxtecan
Topic 15: Novel agents and strategies under investigation for patients with mCRC
 
FACULTY
 
Axel Grothey, MD
Director, GI Cancer Research
West Cancer Center and Research Institute
Chair, OneOncology Research Network
OneOncology
Germantown, Tennessee
 
Michael J Overman, MD
Professor
Department of Gastrointestinal Medical Oncology
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, Texas
 
MODERATOR
 
Neil Love, MD
Research To Practice
Miami, Florida