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Oncology Grand Rounds: Part 3 — PARP Inhibitors in Ovarian Cancer
Released July 2018

Video proceedings from the third in a series of 6 integrated symposia held at the 2018 ONS Annual Congress. Featuring perspectives from Ms Paula J Anastasia, Dr Deborah K Armstrong, Ms Jennifer G Filipi and Dr Richard T Penson. (Video Program)

CE Disclosures and Faculty Information

    This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of ovarian cancer (OC).

    The American Cancer Society estimates that in 2018, more than 14,000 individuals will die of OC, accounting for nearly half of the deaths attributable to all gynecologic cancers. For this reason, significant financial and intellectual resources have been invested over the past few decades in attempts to better understand the natural history of the disease, identify genetic and other factors responsible for its proliferation and develop novel therapies with the potential to significantly improve outcomes for patients. Perhaps the largest recent advance in OC has been the introduction of PARP inhibitors into the therapeutic milieu. However, the paradigm shift brought forth by the availability of PARP inhibitors has significant ramifications for practicing clinicians who must now confront a variety of practical issues, and uncertainties with regard to the safe and efficacious use of these agents persist.

    Although medical and gynecologic oncologists have been routinely responsible for counseling patients with regard to therapeutic decision-making, oncology nurses play an integral role in the successful delivery of systemic anticancer therapy and the preservation of patient physical and psychosocial well-being. These video proceedings from the third part of a 6-part integrated CNE curriculum originally held at the 2018 ONS Annual Congress feature discussions with leading gynecologic oncology investigators and their nursing counterparts regarding actual patient cases and recent clinical research findings affecting the optimal therapeutic and supportive care for each patient scenario.

    By providing information on the latest research developments in the context of expert perspectives, this CNE activity will assist oncology nurses, nurse practitioners and clinical nurse specialists with the formulation of an understanding of the mechanism of action of PARP inhibitors, their role in the clinical algorithm and the unique spectrum of associated side effects to facilitate optimal care of patients with ovarian cancer.


    • Demonstrate knowledge of existing guidelines and consensus statements regarding the rationale for genetic testing and counseling for all patients with newly diagnosed OC regardless of family history.
    • Appreciate available clinical trial data with and approved indications for FDA-endorsed PARP inhibitors to appropriately integrate these agents into the routine care of patients with OC.
    • Understand the dosing requirements and other practical considerations for the use of PARP inhibitors for women with OC to ensure appropriate administration and patient compliance.
    • Describe the potential toxicities of FDA-approved PARP inhibitors, and use this information to design effective monitoring strategies for patients receiving these agents.
    • Develop an evidence-based algorithm for the prevention and amelioration of side effects associated with the use of PARP inhibitors for the treatment of platinum-sensitive and platinum-recurrent advanced OC.
    • Identify opportunities to enhance the collaborative role of oncology nurses in the comprehensive biopsychosocial care of patients with OC to optimize clinical and quality-of-life outcomes.

    Research To Practice (RTP) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s (ANCC) Commission on Accreditation.

    CNE credit is no longer available for this issue

    CNE credit is no longer available for this issue

    This is a video CNE program.
    CNE credit is no longer available for this issue

    RTP is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CNE activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Paula J Anastasia, RN, MN, AOCN
    Gyn-Oncology Clinical Nurse Specialist
    Cedars-Sinai Medical Center
    Los Angeles, California

    Advisory Committee: Merck; Speakers Bureau: Genentech BioOncology.

    Deborah K Armstrong, MD
    Director, Breast and Ovarian Surveillance Service
    Professor of Oncology, Gynecology and Obstetrics
    The Sidney Kimmel Comprehensive Cancer Center
    Johns Hopkins University
    Baltimore, Maryland

    Contracted Research: AstraZeneca Pharmaceuticals LP, Eisai Inc, Exelixis Inc, Pfizer Inc.

    Jennifer G Filipi, MSN, NP
    Massachusetts General Hospital
    Center for Gynecologic Oncology
    Boston, Massachusetts

    No relevant conflicts of interest to disclose.

    Richard T Penson, MD, MRCP
    Associate Professor of Medicine
    Harvard Medical School
    Clinical Director, Medical Oncology
    Massachusetts General Hospital
    Boston, Massachusetts

    Advisory Committee: Amgen Inc, AstraZeneca Pharmaceuticals LP, Eisai Inc, Genentech BioOncology, Roche Laboratories Inc; Consulting Agreement: AstraZeneca Pharmaceuticals LP; Contracted Research: AstraZeneca Pharmaceuticals LP, Baxalta Inc, Clovis Oncology, Eisai Inc, Genentech BioOncology, Merck, Roche Laboratories Inc, Takeda Oncology, Tesaro Inc, Vascular Biogenics Ltd; Data and Safety Monitoring Board: Abbott Laboratories.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME/CNE activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Baxalta Inc, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, CTI BioPharma Corp, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Medivation Inc, a Pfizer Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, NanoString Technologies, Natera Inc, Novartis, Novocure, Onyx Pharmaceuticals, an Amgen subsidiary, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seattle Genetics, Sigma-Tau Pharmaceuticals Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro Inc, Teva Oncology and Tokai Pharmaceuticals Inc.

    RESEARCH TO PRACTICE CME/CNE PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP, Clovis Oncology and Tesaro Inc.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
    Adobe Flash Player 27 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Release date: July 2018
    Expiration date: July 2019

    There is no implied or real endorsement of any product by RTP or the American Nurses Credentialing Center.

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