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Oncology Grand Rounds Series: Part 7 — Melanoma
Released August 2016

Video excerpts from the seventh in a series of 8 integrated symposia held at the 2016 ONS Annual Congress. Featuring perspectives from Ms Katherine Benchich, Dr Adil Daud, Dr Rene Gonzalez, Dr Jason J Luke and Ms Kathleen Madden. (Video Program)

CE Disclosures and Faculty Information

  • TARGET AUDIENCE
    This activity has been designed to meet the educational needs of oncology nurses, nurse practitioners and clinical nurse specialists involved in the treatment of melanoma.

    OVERVIEW OF ACTIVITY
    Despite increased awareness and extensive attempts to publicize risk factors and screening, current estimates suggest that 76,380 men and women will be diagnosed with melanoma and 10,130 individuals will die from the disease in 2016 within the United States alone. Because of its cutaneous location and its high metastatic potential, melanoma management remains a major clinical challenge, and, until recently, treatments for advanced disease had been relatively limited in their overall effectiveness. More recently, unprecedented strides have been made in defining molecular mechanisms of critical importance to melanoma development, progression and metastasis, knowledge which has ultimately yielded a number of new agents that have been heralded as major breakthroughs by the melanoma community.

    This “opening of Pandora’s box” with regard to the availability of new therapies has challenged practicing clinicians to quickly understand how best to safely integrate them into current management algorithms. This is particularly true among oncology nurses and nurse practitioners, who play an integral role in the successful delivery of systemic anticancer therapy and in the preservation of patient physical and psychosocial well-being. These video proceedings from the seventh part of an 8-part integrated CNE curriculum originally held at the 2016 ONS Annual Congress feature discussions with leading dermatologic oncology investigators and their nursing counterparts regarding actual patient cases and recent clinical research findings affecting the optimal therapeutic and supportive care for each patient scenario.

    PURPOSE STATEMENT
    By providing information on the latest research developments in the context of expert perspectives, this CNE activity will assist oncology nurses, nurse practitioners and clinical nurse specialists with the formulation of state-of-the-art clinical management strategies to facilitate optimal care of patients with melanoma.

    LEARNING OBJECTIVES

    • Discuss the benefits and risks associated with systemic therapies used in the evidence-based treatment of adjuvant and metastatic melanoma, including immunotherapeutic strategies and targeted biologic agents.
    • Recognize the FDA approvals of nivolumab, pembrolizumab and the combination of nivolumab and ipilimumab for the management of metastatic melanoma, and understand how these approaches fit into current treatment algorithms.
    • Recall existing and emerging research information demonstrating the impact of combining BRAF and MEK inhibitors for patients with BRAF mutation-positive metastatic melanoma, and use this information to guide treatment planning for these individuals.
    • Develop a plan to manage the side effects associated with immune checkpoint inhibitors and novel targeted agents to support quality of life and continuation of treatment.
    • Appreciate the novel mechanism of action, endorsed clinical role and practical administration requirements of talimogene laherparepvec to support the safe and effective integration of this agent into current patient care.

    ACCREDITATION STATEMENT
    Research To Practice is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

    CREDIT DESIGNATION STATEMENTS
    This educational activity for 1.7 contact hours is provided by Research To Practice during the period of August 2016 through August 2017.

    This activity is awarded 1.7 ANCC pharmacotherapeutic contact hours.

    ONCC/ILNA CERTIFICATION INFORMATION
    The program content has been reviewed by the Oncology Nursing Certification Corporation (ONCC) and is acceptable for recertification points. To review certification qualifications please visit ResearchToPractice.com/ONS2016/ILNA.

    ONCC review is only for designating content to be used for recertification points and is not for CNE accreditation. CNE programs must be formally approved for contact hours by an acceptable accreditor/approver of nursing CE to be used for recertification by ONCC. If the CNE provider fails to obtain formal approval to award contact hours by an acceptable accrediting/approval body, no information related to ONCC recertification may be used in relation to the program.

    FOR SUCCESSFUL COMPLETION
    This is a video CNE program. To receive credit, participants should read the learning objectives and faculty disclosures, watch the video, complete the Post-test with a score of 75% or better and fill out the Educational Assessment and Credit Form located at ResearchToPractice.com/ONSMelanoma2016/CNE.

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CNE activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:

    Katherine Benchich, MSN, ANP, OCN
    University of Colorado Cancer Center
    Cutaneous Oncology
    Aurora, Colorado

    No relevant conflicts of interest to disclose.

    Adil Daud, MD
    Professor of Medicine
    University of California
    San Francisco, California

    Advisory Committee: Amgen Inc, Genentech BioOncology, GlaxoSmithKline, OncoSec Medical; Consulting Agreements: Bristol-Myers Squibb Company, Merck, Novartis Pharmaceuticals Corporation, OncoSec Medical, Takeda Oncology; Contracted Research: Bristol-Myers Squibb Company, Genentech BioOncology, GlaxoSmithKline, Merck, Novartis Pharmaceuticals Corporation, Pfizer Inc, Roche Laboratories Inc, Takeda Oncology.

    Rene Gonzalez, MD
    Professor of Medicine
    Director, Melanoma Research Clinics
    University of Colorado Cancer Center
    Aurora, Colorado

    Advisory Committee: Amgen Inc, Bristol-Myers Squibb Company, Genentech BioOncology, GlaxoSmithKline, Roche Laboratories Inc; Consulting Agreements: Amgen Inc, Genentech BioOncology, GlaxoSmithKline, Novartis Pharmaceuticals Corporation; Contracted Research: Amgen Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Castle Biosciences Incorporated, Eisai Inc, Genentech BioOncology, GlaxoSmithKline, Merck, Novartis Pharmaceuticals Corporation, Roche Laboratories Inc, Takeda Oncology; Other Remunerated Activities: Novartis Pharmaceuticals Corporation.

    Jason J Luke, MD
    Assistant Professor of Medicine
    University of Chicago
    Chicago, Illinois

    Consulting Agreements: Amgen Inc, Array BioPharma Inc; Contracted Research: AbbVie Inc, BBI Therapeutics, Bristol-Myers Squibb Company, Celldex Therapeutics, Corvus Pharmaceuticals, Delcath Systems Inc, EMD Serono Inc, Five Prime Therapeutics Inc, Genentech BioOncology, Incyte Corporation, MedImmune Inc, Merck, Novartis Pharmaceuticals Corporation, Pharmacyclics LLC, an AbbVie Company.

    Kathleen Madden, MSN, FNP, AOCNP, APHN
    NYU Langone Perlmutter Cancer Center
    New York University
    New York, New York

    Consulting Agreement: Novartis Pharmaceuticals Corporation; Speakers Bureau: Bristol-Myers Squibb Company, Daiichi Sankyo Inc, Genentech BioOncology, Merck, Novartis Pharmaceuticals Corporation.

    MODERATORDr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME/CNE activities from the following commercial interests: AbbVie Inc, Acerta Pharma, Agendia Inc, Amgen Inc, Array BioPharma Inc, Astellas Pharma Global Development Inc, AstraZeneca Pharmaceuticals LP, Baxalta Inc, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Pharma Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, CTI BioPharma Corp, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, Exelixis Inc, Foundation Medicine, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Janssen Biotech Inc, Jazz Pharmaceuticals Inc, Lilly, Medivation Inc, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, NanoString Technologies, Natera Inc, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals, an Amgen subsidiary, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Sigma-Tau Pharmaceuticals Inc, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Teva Oncology, Tokai Pharmaceuticals Inc and VisionGate Inc. 

    RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.

    This activity is supported by educational grants from Amgen Inc, Genentech BioOncology, Merck and Novartis Pharmaceuticals Corporation.

    Hardware/Software Requirements:
    A high-speed Internet connection
    A monitor set to 1280 x 1024 pixels or more
    Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later
    Adobe Flash Player 10.2 plug-in or later
    Adobe Acrobat Reader
    (Optional) Sound card and speakers for audio

    Last review date: August 2016
    Expiration date: August 2017

    There is no implied or real endorsement of any product by RTP or the American Nurses Credentialing Center.

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