CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This live activity has been designed to meet the educational needs of medical oncologists, hematologists, hematology-oncology fellows, nurse practitioners, clinical nurse specialists and other allied cancer professionals involved in the treatment of cancer.
  
  LEARNING OBJECTIVES

  • Effectively apply the results of practice-changing clinical research to the care of patients with breast, gastrointestinal, genitourinary, lung and select hematologic cancers.
  • Appraise the clinical relevance of recent pivotal cancer research results published in peer-reviewed journals or presented at major oncology conferences.
  • Recall ongoing trials in breast, gastrointestinal, genitourinary, lung and select hematologic cancers, and refer appropriate patients for study participation.
  • Incorporate clinical characteristics, logistical factors, tumor biomarkers and single and multigene signatures in the individualization of care for patients with cancer.
  • Educate patients with diverse hematologic cancers and solid tumors about the benefits and risks of new therapeutic agents and strategies.
  • Refine or validate existing cancer treatment algorithms on the basis of new data sets and the perspectives of tumor-specific clinical investigators.
  • Evaluate the mechanisms of action, tolerability and efficacy of promising investigational agents, and consider the implications for clinical practice.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  CME credit is no longer available for this issue
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  Audio Program: This CME activity consists of an audio component.
  CME credit is no longer available for this issue
  
  Video Program: This CME activity consists of a video component.
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty reported relevant conflicts of interest, which have been mitigated through a conflict of interest mitigation process:
  
  Courtney D DiNardo, MD, MSCE
  Associate Professor, Department of Leukemia
  Division of Cancer Medicine
  The University of Texas MD Anderson Cancer Center
  Houston, Texas
  
  Advisory Committee: Foghorn Therapeutics, Gilead Sciences Inc, Immune-Onc Therapeutics Inc, Novartis, Takeda Oncology; Consulting Agreements: AbbVie Inc, Agios Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Genentech, a member of the Roche Group; Contracted Research: AbbVie Inc, Agios Pharmaceuticals Inc, Astex Pharmaceuticals, Bristol-Myers Squibb Company, Calithera Biosciences, Celgene Corporation, Cleave Therapeutics, Daiichi Sankyo Inc, Immune-Onc Therapeutics Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company; Scientific Advisory Board with Stock Options: Notable Labs.
  
  Robert Dreicer, MD, MS
  Section Head, Medical Oncology
  Deputy Director, University of Virginia Cancer Center
  Associate Director for Clinical Research
  Professor of Medicine and Urology
  University of Virginia School of Medicine
  Charlottesville, Virginia
  
  Advisory Committee: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Eisai Inc, EMD Serono Inc, Exelixis Inc, Myovant Sciences, Pfizer Inc, Propella Therapeutics Inc, Tavanta Therapeutics, Veru; Data and Safety Monitoring Board/Committee: Hinova Pharmaceuticals Inc, Merck.
  
  Justin F Gainor, MD
  Director, Center for Thoracic Cancers at Massachusetts General Hospital
  Director of Targeted Immunotherapy in the Henri and Belinda Termeer
  Center for Targeted Therapies
  Assistant Professor of Medicine at Harvard Medical School
  Massachusetts General Hospital
  Boston, Massachusetts
  
  Consulting Agreements: Agios Pharmaceuticals Inc, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, AstraZeneca Pharmaceuticals LP, Blueprint Medicines, Bristol-Myers Squibb Company, Genentech, a member of the Roche Group, Gilead Sciences Inc, Helsinn Healthcare SA, Incyte Corporation, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Novartis, Oncorus, Pfizer Inc, Regeneron Pharmaceuticals Inc, Takeda Oncology; Contracted Research: Adaptimmune, ALX Oncology, Array BioPharma Inc, a subsidiary of Pfizer Inc, Blueprint Medicines, Bristol-Myers Squibb Company, Genentech, a member of the Roche Group, Jounce Therapeutics, Merck, Moderna, Novartis, Scholar Rock, Takeda Oncology, Tesaro, A GSK Company; Employment (Immediate Family Member): Ironwood Pharmaceuticals.
  
  Sara Hurvitz, MD
  Professor of Medicine
  David Geffen School of Medicine at UCLA
  Director, Breast Cancer Clinical Research Program
  Co-Director, Santa Monica-UCLA Outpatient Oncology Practice
  Santa Monica, California
  
  Consulting Agreement (Stock Investment): NKMax America; Contracted Research: Ambrx Inc, Amgen Inc, Arvinas, Bayer HealthCare Pharmaceuticals, Daiichi Sankyo Inc, Dignitana, Genentech, a member of the Roche Group, GlaxoSmithKline, Immunomedics Inc, Lilly, MacroGenics Inc, Novartis, OBI Pharma Inc, Pfizer Inc, Pieris Pharmaceuticals Inc, Puma Biotechnology Inc, Radius Health Inc, Sanofi Genzyme, Seagen Inc, Zymeworks; Paid Travel: Lilly; Stocks (Spouse): IDEAL IMPLANT, ROMTech.
  
  Ian E Krop, MD, PhD
  Associate Chief, Division of Breast Oncology
  Dana-Farber Cancer Institute
  Associate Professor of Medicine
  Harvard Medical School
  Boston, Massachusetts
  
  Consulting Agreements: AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, MacroGenics Inc; Contracted Research: Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Pfizer Inc, Taiho Oncology Inc; Data and Safety Monitoring Board/Committee: Merck, Novartis.
  
  John M Pagel, MD, PhD
  Chief of Hematologic Malignancies Program
  Center for Blood Disorders and Stem Cell Transplantation
  Swedish Cancer Institute
  Seattle, Washington
  
  Consulting Agreements: AstraZeneca Pharmaceuticals LP, BeiGene, Epizyme Inc, Gilead Sciences Inc, MorphoSys, Seagen Inc.
  
  Alexander Perl, MD
  Associate Professor of Medicine
  Perelman School of Medicine
  Member, Leukemia Program
  Abramson Cancer Center
  University of Pennsylvania
  Philadelphia, Pennsylvania
  
  Advisory Committee: AbbVie Inc, Actinium Pharmaceuticals Inc, Astellas, Bristol-Myers Squibb Company, Celgene Corporation, Genentech, a member of the Roche Group, Daiichi Sankyo Inc, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Syndax Pharmaceuticals Inc; Consulting Agreements: AbbVie Inc, Astellas, Daiichi Sankyo Inc, FORMA Therapeutics, Onconova Therapeutics Inc, Sumitomo Dainippon Pharma Oncology Inc; Contracted Research (All Monies to Institution): AbbVie Inc, Actinium Pharmaceuticals Inc, Astellas, Daiichi Sankyo Inc, FUJIFILM Pharmaceuticals USA Inc; Data and Safety Monitoring Board/Committee: Beat AML LLC, Leukemia & Lymphoma Society.
  
  Daniel P Petrylak, MD
  Professor of Internal Medicine (Medical Oncology) and Urology
  Yale School of Medicine
  New Haven, Connecticut
  
  Consulting Agreements: Advanced Accelerator Applications, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bicycle Therapeutics, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Clovis Oncology, Exelixis Inc, Incyte Corporation, Janssen Biotech Inc, Lilly, Mirati Therapeutics, Monopteros Therapeutics, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Roche Laboratories Inc, Seagen Inc, UroGen Pharma; Contracted Research: Advanced Accelerator Applications, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BioXcel Therapeutics Inc, Bristol-Myers Squibb Company, Clovis Oncology, Eisai Inc, Endocyte Inc, Genentech, a member of the Roche Group, Innocrin Pharmaceuticals Inc, Lilly, Medivation Inc, a Pfizer Company, Merck, Mirati Therapeutics, Novartis, Pfizer Inc, Progenics Pharmaceuticals Inc, Replimune, Roche Laboratories Inc, Sanofi Genzyme, Seagen Inc; Ownership Interest: Bellicum Pharmaceuticals Inc (sold 7/2020), Tyme Inc (sold 10/2019).
  
  Philip A Philip, MD, PhD, FRCP
  Kathryn Cramer Endowed Chair in Cancer Research
  Professor of Oncology and Pharmacology
  Leader, GI and Neuroendocrine Oncology
  Karmanos Cancer Institute
  Wayne State University
  Detroit, Michigan
  
  Advisory Committee: Array BioPharma Inc, a subsidiary of Pfizer Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Celgene Corporation, Daiichi Sankyo Inc, Eisai Inc, Ipsen Biopharmaceuticals Inc, Merck, Merus BV, Pfizer Inc, QED Therapeutics, Rafael Pharmaceuticals Inc; Consulting Agreements: Blueprint Medicines, Erytech, SynCore Biotechnology Co Ltd, TriSalus Life Sciences; Contracted Research: Astellas, Bayer HealthCare Pharmaceuticals, BeiGene, Bristol-Myers Squibb Company, Celgene Corporation, Five Prime Therapeutics Inc, Forty Seven Inc, Incyte Corporation, Karyopharm Therapeutics, Merck, Merus BV, Novartis, Novocure, QED Therapeutics, Rafael Pharmaceuticals Inc, SynCore Biotechnology Co Ltd, Taiho Oncology Inc, Tyme Inc; Data and Safety Monitoring Board/Committee: ASLAN Pharmaceuticals, Blueprint Medicines, Erytech; Speakers Bureau: Advanced Accelerator Applications, Celgene Corporation, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Novartis.
  
  Paul G Richardson, MD
  Clinical Program Leader and Director of Clinical Research
  Jerome Lipper Multiple Myeloma Center
  Dana-Farber Cancer Institute
  RJ Corman Professor of Medicine
  Harvard Medical School
  Boston, Massachusetts
  
  Advisory Committee: Bristol-Myers Squibb Company, Celgene Corporation, GlaxoSmithKline, Janssen Biotech Inc, Karyopharm Therapeutics, Oncopeptides, Sanofi Genzyme, Secura Bio Inc, Takeda Oncology; Contracted Research: Bristol-Myers Squibb Company, Celgene Corporation, Oncopeptides, Takeda Oncology.
  
  Mitchell R Smith, MD, PhD
  Clinical Professor of Medicine
  George Washington University
  Washington, DC
  
  Advisory Committee: Pharmacyclics LLC, an AbbVie Company; Contracted Research: Karyopharm Therapeutics; Speakers Bureau: Acrotech Biopharma, AstraZeneca Pharmaceuticals LP.
  
  Eric Van Cutsem, MD, PhD
  Professor of Medicine
  Digestive Oncology
  University Hospitals Leuven
  Leuven, Belgium
  
  Consulting Agreements: Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biocartis, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, GlaxoSmithKline, Halozyme Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Lilly, Merck KGaA, Merck Sharp & Dohme Corp, Novartis, Pierre Fabre, Roche Laboratories Inc, Servier, Sirtex Medical Ltd, Taiho Oncology Inc; Contracted Research: Amgen Inc, Bayer HealthCare Pharmaceuticals, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Ipsen Biopharmaceuticals Inc, Lilly, Merck KGaA, Merck Sharp & Dohme Corp, Novartis, Roche Laboratories Inc, Servier.
  
  Peter Voorhees, MD
  Professor of Medicine
  Member, Plasma Cell Disorders Division
  Levine Cancer Institute, Atrium Health
  Charlotte, North Carolina
  
  Advisory Committee: AbbVie Inc, Bristol-Myers Squibb Company; Consulting Agreements: GlaxoSmithKline, Novartis, Oncopeptides; Data and Safety Monitoring Board/Committee: Bristol-Myers Squibb Company.
  
  Heather Wakelee, MD
  Professor of Medicine, Division of Oncology
  Faculty Director, Stanford Cancer Clinical Trials Office
  Stanford University School of Medicine
  Stanford Cancer Institute
  Stanford, California
  
  Advisory Committee: AstraZeneca Pharmaceuticals LP, Blueprint Medicines, Daiichi Sankyo Inc, Genentech, a member of the Roche Group, Helsinn Healthcare SA, Janssen Biotech Inc, Merck, Mirati Therapeutics, Xcovery; Research Funding to Institution: ACEA Biosciences Inc, Arrys Therapeutics, a wholly owned subsidiary of Kyn Therapeutics, AstraZeneca Pharmaceuticals LP, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Exelixis Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Merck, Novartis, Pharmacyclics LLC, an AbbVie Company, Seagen Inc, Xcovery.
  
  MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: AbbVie Inc, Adaptive Biotechnologies Corporation, Agios Pharmaceuticals Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Eisai Inc, Epizyme Inc, Exact Sciences Inc, Exelixis Inc, Five Prime Therapeutics Inc, Foundation Medicine, Genentech, a member of the Roche Group, Gilead Sciences Inc, GlaxoSmithKline, Grail Inc, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Novartis, Novocure Inc, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seagen Inc, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Turning Point Therapeutics Inc and Verastem Inc.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  This activity is supported by educational grants from AbbVie Inc, Astellas and Pfizer Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, BeiGene, Blueprint Medicines, Daiichi Sankyo Inc, Epizyme Inc, Exelixis Inc, Genentech, a member of the Roche Group, Gilead Sciences Inc, Incyte Corporation, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Lilly, Merck, Novartis, Oncopeptides, Sanofi Genzyme, and Seagen Inc.
  
  Release date: May 2021
  Expiration date: May 2022