CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This program is intended for medical oncologists, hematologists, hematology-oncology fellows and other allied healthcare professionals involved in the treatment of lung cancer.
  
  LEARNING OBJECTIVES

  • Recognize the spectrum of oncogenic alterations beyond those associated with EGFR identifiable in patients with non-small cell lung cancer (NSCLC), and determine how these may predict potential response to novel targeted therapies.
  • Appraise the efficacy and safety of approved and investigational ALK inhibitors, and determine how these agents can be integrated into the protocol and nonresearch care of patients with NSCLC with ALK rearrangements.
  • Consider the mechanism of action of entrectinib, available data and the FDA approval of that agent for patients with NSCLC with ROS1 alterations, and discern how it can be appropriately and safely integrated into routine clinical care.
  • Assess available clinical trial findings supporting the FDA approvals of capmatinib and tepotinib for metastatic NSCLC with MET exon 14 skipping mutations, and identify patients who might benefit from these agents.
  • Recall the FDA approvals of selpercatinib and pralsetinib for patients with RET-driven metastatic NSCLC, and evaluate how these agents should be appropriately and safely integrated into clinical practice.
  • Recollect other oncogenic pathways (ie, HER2, KRAS) mediating the pathogenesis of tumors in unique patient subsets, and recall published and emerging data with commercially available and experimental agents exploiting these targets.
  • Recognize common and rare side effects associated with novel targeted agents employed in the treatment of NSCLC, and use this information to develop supportive management plans for patients.
  • Assess ongoing clinical research evaluating novel agents and treatment strategies for patients with NSCLC harboring actionable mutations beyond EGFR, and offer counsel about the potential benefits of trial participation.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  CME credit is no longer available for this issue
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  Audio Program: This CME activity consists of an audio component.
  CME credit is no longer available for this issue
  
  Video Program: This CME activity consists of a video component.
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty reported relevant financial relationships with ineligible entities:
  
  D Ross Camidge, MD, PhD
  Professor of Medicine/Oncology
  Joyce Zeff Chair in Lung Cancer Research
  University of Colorado, Anschutz Medical Campus
  Denver, Colorado
  
  Advisory Committee: Apollomics Inc, AstraZeneca Pharmaceuticals LP, Elevation Oncology, Kestrel Lifesciences, Nuvalent; Consulting Agreements: AbbVie Inc, Amgen Inc, AnHeart Therapeutics, Blueprint Medicines, EMD Serono Inc, Genentech, a member of the Roche Group, Janssen Biotech Inc, Medtronic Inc, Mersana Therapeutics Inc, Mirati Therapeutics, OnKure Therapeutics, Ribon Therapeutics, Roche Laboratories Inc, Sanofi Genzyme, Seagen Inc, Takeda Pharmaceuticals USA Inc, Turning Point Therapeutics Inc; Data and Safety Monitoring Board/Committee: BeiGene Ltd, Biothera Pharmaceuticals Inc, Helsinn Healthcare SA, Hengrui Therapeutics Inc, Lilly; Stock: Kestrel Lifesciences; Other: AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Mersana Therapeutics Inc (ILD adjudication committee); Puma Biotechnology Inc (NCCN grant review).
  
  MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: AbbVie Inc, Adaptive Biotechnologies Corporation, ADC Therapeutics, Agios Pharmaceuticals Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, BeyondSpring Pharmaceuticals Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Coherus BioSciences, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, Epizyme Inc, Exact Sciences, Exelixis Inc, Five Prime Therapeutics Inc, Foundation Medicine, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Genmab, Gilead Sciences Inc, GlaxoSmithKline, Grail Inc, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Seagen Inc, Servier Pharmaceuticals LLC, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, Tesaro, A GSK Company, TG Therapeutics Inc, Turning Point Therapeutics Inc, Verastem Inc and Zymeworks Inc.
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  These activities are supported by educational grants from Amgen Inc, AstraZeneca Pharmaceuticals LP, Daiichi Sankyo Inc, Elevation Oncology Inc, Genentech, a member of the Roche Group, Novartis, and Turning Point Therapeutics Inc.
  
  Release date: May 2022
  Expiration date: May 2023