CE Disclosures and Faculty Information

• TARGET AUDIENCE
  This activity is intended for gynecologic oncologists and other healthcare providers involved in the treatment of ovarian, cervical and endometrial cancer.
  
  OVERVIEW OF ACTIVITY
  
  In 2014 it is anticipated that approximately 94,990 new cases of gynecologic cancer — which includes cancer of the ovaries, uterine corpus (endometrial cancer), uterine cervix (cervical cancer), vulva and vagina — will be documented in the United States and 28,790 individuals will succumb to these diseases. As with many other tumors, patient outcomes are critically dependent on effective multidisciplinary care. Despite many commonalities, each of these diseases is in fact quite distinct, and in this regard management algorithms employed for each are varied.

  Existing and emerging multimodality treatment regimens used in the routine management of these diseases necessitate the physician’s working knowledge of novel surgical, radiation and systemic therapeutic techniques. Ongoing clinical trials will continue to refine the optimal management of these tumors, and the introduction of innovative, targeted compounds may offer individualized treatment options that provide increased efficacy and improved tolerability. In order to offer optimal patient care — including the option of clinical trial participation — clinicians who care for patients with gynecologic cancers must be well informed of these advances. By providing information on the latest research developments and their potential application to routine practice, this activity is designed to assist gynecologic oncologists and other healthcare providers with the formulation of up-to-date clinical management strategies for various gynecologic cancers.
  
  LEARNING OBJECTIVES

  • Employ current clinical guidelines and available data in the selection of treatment options for patients with commonly diagnosed gynecologic cancers.
  • Apply the results of emerging research with angiogenesis inhibition to the development of therapeutic strategies for patients with advanced epithelial ovarian cancer.
  • Summarize available research data on the activity of PARP inhibitors in patients with advanced ovarian cancer with or without BRCA mutations.
  • Appreciate emerging clinical trial data documenting the benefit of anti-angiogenic therapy in combination with chemotherapy for patients with metastatic, recurrent or persistent cervical cancer, and consider this information in treatment decision-making.
  • Develop an understanding of the emerging efficacy data and toxicity profiles of investigational agents in common gynecologic cancers to effectively prioritize clinical trial opportunities for appropriate patients.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CME credit is no longer available for this issue
  
  CREDIT DESIGNATION STATEMENT
  
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  This CME activity consists of a video component. The participant should watch the video.
  
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess potential conflicts of interest with faculty, planners and managers of CME activities. Real or apparent conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY — The following faculty (and their spouses/partners) reported real or apparent conflicts of interest, which have been resolved through a conflict of interest resolution process:
  
  Bradley J Monk, MD
  Professor and Director
  Division of Gynecologic Oncology
  Department of Obstetrics and Gynecology
  University of Arizona Cancer Center
  Creighton University School of Medicine at
  St Joseph’s Hospital and Medical Center, A Dignity Health Member
  Phoenix, Arizona
  
  Consulting Agreements: Arno Therapeutics Inc, Boehringer Ingelheim Pharmaceuticals Inc, Celgene Corporation, GlaxoSmithKline, INSYS Therapeutics Inc, Merck, QIAGEN, TESARO Inc; Contracted Research: Amgen Inc, Array BioPharma Inc, Genentech BioOncology, Janssen Pharmaceuticals Inc, Johnson & Johnson Pharmaceuticals, Lilly, Novartis Pharmaceuticals Corporation; Speakers Bureau: Genentech BioOncology, Roche Laboratories Inc.
  
  Ursula A Matulonis, MD
  Medical Director and Program Leader
  Gynecologic Oncology Program
  Associate Professor of Medicine
  Harvard Medical School
  Dana-Farber Cancer Institute
  Boston, Massachusetts
  
  Advisory Committee: Clovis Oncology, Momenta Pharmaceuticals Inc, Novartis Pharmaceuticals Corporation.
  
  Don S Dizon, MD
  Director
  Oncology Sexual Health Clinic
  Medical Gynecologic Oncology
  Gillette Center for Women’s Cancers
  Massachusetts General Hospital
  Boston, Massachusetts
  
  No real or apparent conflicts of interest to disclose.
  
  Robert A Burger, MD
  Professor, Department of Obstetrics and Gynecology
  Director of Clinical Research and Fellowship Program
  Division of Gynecologic Oncology
  University of Pennsylvania
  Philadelphia, Pennsylvania
  
  Advisory Committee: Amgen Inc, Boehringer Ingelheim Pharmaceuticals Inc, Clovis Oncology, Genentech BioOncology.
  
  MODERATOR — Dr Love is president and CEO of Research To Practice, which receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Algeta US, Amgen Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Biodesix Inc, Biogen Idec, Boehringer Ingelheim Pharmaceuticals Inc, Bristol-Myers Squibb Company, Celgene Corporation, Daiichi Sankyo Inc, Dendreon Corporation, Eisai Inc, Exelixis Inc, Genentech BioOncology, Genomic Health Inc, Gilead Sciences Inc, Incyte Corporation, Lilly, Medivation Inc, Merck, Millennium: The Takeda Oncology Company, Novartis Pharmaceuticals Corporation, Novocure, Onyx Pharmaceuticals Inc, Prometheus Laboratories Inc, Regeneron Pharmaceuticals, Sanofi, Seattle Genetics, Spectrum Pharmaceuticals Inc, Teva Oncology and VisionGate Inc.
  
  RESEARCH TO PRACTICE STAFF AND EXTERNAL REVIEWERS — The scientific staff and reviewers for Research To Practice have no real or apparent conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  This activity is supported by educational grants from AstraZeneca Pharmaceuticals LP and Genentech BioOncology.
  
  Hardware/Software Requirements:
  A high-speed Internet connection

  A monitor set to 1280 x 1024 pixels or more

  Internet Explorer 7 or later, Firefox 3.0 or later, Chrome, Safari 3.0 or later

  Adobe Flash Player 10.2 plug-in or later

  Adobe Acrobat Reader

  (Optional) Sound card and speakers for audio
  
  Last review date: July 2014
  Expiration date: July 2015