Proceedings from Part 2 of a 2-part satellite symposia series during the 61st ASH Annual Meeting. Featuring perspectives from Drs Jesús G Berdeja, Sagar Lonial, María-Victoria Mateos, Nikhil C Munshi, Robert Z Orlowski and Noopur Raje. (Video Program)
TARGET AUDIENCE
This activity is intended for hematologists, medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of multiple myeloma (MM), Waldenström macroglobulinemia (WM) and amyloidosis.
OVERVIEW OF ACTIVITY
Hematologic cancers include the lymphomas, the leukemias, MM and other related disorders stemming from lymphoid and myeloid progenitor cell lines. Taken together, it is estimated that approximately 176,200 new lymphoid, myeloid and leukemic cancer cases were identified in the United States in the year 2019, and 56,770 individuals died from these diseases. Importantly, more than 70 drug products are currently labeled for use in the management of hematologic cancers with more than 120 distinct FDA-approved indications. Although this extensive list of available treatment options is reassuring for patients and oncology healthcare professionals, it poses a challenge to the practicing clinician who must maintain up-to-date knowledge of their appropriate application across a vast spectrum of tumor types. This is particularly true within the realm of MM, WM and amyloidosis, where the past several years have yielded a staggering number of important clinical and research advances.
These proceedings from a CME symposium during the ASH Annual Meeting use the perspectives of a group of community oncologists/hematologists gathered during a daylong working group to establish and subsequently address some of the most frequently encountered questions and controversies facing clinicians involved in the management of these diseases. By providing information on the latest research developments and their potential application to routine practice, this activity is designed to assist hematologists, medical oncologists, hematology-oncology fellows and other healthcare providers involved in the treatment of MM, WM and amyloidosis with the formulation of up-to-date clinical management strategies.
LEARNING OBJECTIVES
ACCREDITATION STATEMENT
Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
CREDIT DESIGNATION STATEMENT
CME credit is no longer available for this issue
AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
CME credit is no longer available for this issue
HOW TO USE THESE CME ACTIVITIES
This CME activity consists of a video component.
CME credit is no longer available for this issue
CONTENT VALIDATION AND DISCLOSURES
Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education. We assess conflicts of interest with faculty, planners and managers of CME activities. Conflicts of interest are identified and resolved through a conflict of interest resolution process. In addition, all activity content is reviewed by both a member of the RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
FACULTY — The following faculty (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:
Jesús G Berdeja, MD
Director of Myeloma Research
Sarah Cannon Research Institute
Nashville, Tennessee
Consulting Agreements: Amgen Inc, Bioclinica, Bristol-Myers Squibb Company, Celgene Corporation, CRISPR Therapeutics, Janssen Biotech Inc, Karyopharm Therapeutics, Kite Pharma Inc, Servier, Takeda Oncology; Contracted Research: AbbVie Inc, Acetylon Pharmaceuticals Inc, Amgen Inc, bluebird bio, Bristol-Myers Squibb Company, Celgene Corporation, Constellation Pharmaceuticals, Curis Inc, Genentech, Glenmark, Janssen Biotech Inc, Kesios Therapeutics Ltd, Lilly, Novartis, Poseida Therapeutics, Sanofi Genzyme, Takeda Oncology, Teva Oncology, Vivolux; Data and Safety Monitoring Board: Prothena.
Sagar Lonial, MD
Chair and Professor
Department of Hematology and Medical Oncology
Chief Medical Officer
Winship Cancer Institute
Emory University
Atlanta, Georgia
Consulting Agreements: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, GlaxoSmithKline, Janssen Biotech Inc, Takeda Oncology.
María-Victoria Mateos, MD, PhD
Director, Myeloma Unit
University Hospital of Salamanca
Salamanca, Spain
Advisory Committee: AbbVie Inc, Amgen Inc, Celgene Corporation, Genentech, GlaxoSmithKline, Janssen Biotech Inc, Mundipharma EDO GmbH, PharmaMar, Roche Laboratories Inc, Takeda Oncology; Data Monitoring Committee: Amgen Inc, Janssen Biotech Inc; Speakers Bureau: Amgen Inc, Celgene Corporation, Janssen Biotech Inc, Takeda Oncology.
Nikhil C Munshi, MD
Professor of Medicine, Harvard Medical School
Director of Basic and Correlative Science
Associate Director, Jerome Lipper Multiple Myeloma Center
Department of Medical Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts
Consulting Agreements: AbbVie Inc, Adaptive Biotechnologies, Amgen Inc, BeiGene, Celgene Corporation, Janssen Biotech Inc, Karyopharm Therapeutics, OncoPep, Takeda Oncology; Ownership Interest: OncoPep.
Robert Z Orlowski, MD, PhD
Florence Maude Thomas Cancer Research Professor
Department of Lymphoma and Myeloma
Professor, Department of Experimental Therapeutics
Director, Myeloma Section
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, Texas
Consulting Agreements: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, Janssen Biotech Inc, Kite Pharma Inc, Sanofi Genzyme, Takeda Oncology; Contracted Research: Amgen Inc, BioTheryX Inc, Spectrum Pharmaceuticals Inc.
Noopur Raje, MD
Director, Center for Multiple Myeloma
Massachusetts General Hospital Cancer Center
Professor of Medicine
Harvard Medical School
Boston, Massachusetts
Consulting Agreements: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, Janssen Biotech Inc, Merck, Takeda Oncology; Contracted Research: AstraZeneca Pharmaceuticals LP.
CONSULTING ONCOLOGISTS/HEMATOLOGISTS — The following consulting oncologists/hematologists (and their spouses/partners) reported relevant conflicts of interest, which have been resolved through a conflict of interest resolution process:
Warren S Brenner, MD
Lynn Cancer Institute
Boca Raton, Florida
Speakers Bureau: Celgene Corporation, Takeda Oncology.
Gautam Kale, MD, MS
Hematology (Lead) and Oncology Staff Physician
Cone Health Cancer Center
Greensboro, North Carolina
No relevant conflicts of interest to disclose.
Khuda Dad Khan, MD, PhD
Hematology, Oncology, Immunology
Norton Cancer Institute
Norton Audubon Hospital
Louisville, Kentucky
Consulting Agreement: Novartis; Speakers Bureau: Alexion Pharmaceuticals, Genentech, Novartis.
Zanetta S Lamar, MD
Florida Cancer Specialists and Research Institute
Naples, Florida
No relevant conflicts of interest to disclose.
Neil Morganstein, MD
Hematology Oncology
Atlantic Health System
Summit, New Jersey
No relevant conflicts of interest to disclose.
Namrata I Peswani, MD
Hematology Oncology/Palliative Care
Advocate Medical Group
Orland Park, Illinois
No relevant conflicts of interest to disclose.
MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following commercial interests: AbbVie Inc, Acerta Pharma — A member of the AstraZeneca Group, Adaptive Biotechnologies, Agendia Inc, Agios Pharmaceuticals Inc, Amgen Inc, Ariad Pharmaceuticals Inc, Array BioPharma Inc, Astellas, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Biodesix Inc, bioTheranostics Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Boston Biomedical Inc, Bristol-Myers Squibb Company, Celgene Corporation, Clovis Oncology, Daiichi Sankyo Inc, Dendreon Pharmaceuticals Inc, Eisai Inc, EMD Serono Inc, Exelixis Inc, Foundation Medicine, Genentech, Genmab, Genomic Health Inc, Gilead Sciences Inc, Guardant Health, Halozyme Inc, ImmunoGen Inc, Incyte Corporation, Infinity Pharmaceuticals Inc, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Kite Pharma Inc, Lexicon Pharmaceuticals Inc, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Merrimack Pharmaceuticals Inc, Myriad Genetic Laboratories Inc, Natera Inc, Novartis, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Prometheus Laboratories Inc, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, Sandoz Inc, a Novartis Division, Sanofi Genzyme, Seattle Genetics, Sirtex Medical Ltd, Spectrum Pharmaceuticals Inc, Taiho Oncology Inc, Takeda Oncology, Tesaro, A GSK Company, Teva Oncology, Tokai Pharmaceuticals Inc and Tolero Pharmaceuticals.
RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
This activity is supported by an educational grant from AbbVie Inc, Adaptive Biotechnologies, AstraZeneca Pharmaceuticals LP, Celgene Corporation, Genentech, Gilead Sciences Inc, Pharmacyclics LLC, an AbbVie Company, and Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC.
Hardware/Software Requirements:
A high-speed Internet connection
A monitor set to 1280 x 1024 pixels or more
Internet Explorer 11 or later, Firefox 56 or later, Chrome 61 or later, Safari 11 or later, Opera 48 or later
Adobe Flash Player 27 plug-in or later
Adobe Acrobat Reader
(Optional) Sound card and speakers for audio
Release date: February 2020
Expiration date: February 2021
(WIFI is recommended for best performance):