CE Information and Faculty Disclosures

• TARGET AUDIENCE
  This program is intended for medical oncologists, hematologists, hematology-oncology fellows and other allied healthcare professionals involved in the treatment of multiple myeloma.
  
  LEARNING OBJECTIVES

  • Customize the use of induction, consolidation and maintenance therapeutic approaches for multiple myeloma (MM) in transplant and nontransplant settings, considering patient- and disease-related factors including cytogenetic profile.
  • Appreciate clinical trial data informing the use of monoclonal antibody therapy directed at CD38 for patients with newly diagnosed and relapsed/refractory (R/R) MM, and effectively identify when and how these agents should be integrated into clinical management.
  • Consider published research findings and other clinical factors in the best-practice selection, sequencing and combining of established regimens in the care of patients with R/R MM.
  • Develop an understanding of the mechanisms of action of and pivotal clinical trial findings with recently FDA-approved novel therapies (eg, isatuximab, selinexor, belantamab mafodotin) to facilitate their integration into MM management algorithms.
  • Evaluate the biologic rationale for the use of chimeric antigen receptor T-cell therapy directed at B-cell maturation antigen as a targeted therapeutic strategy for MM, and identify patients for whom treatment with this novel approach should be considered.
  • Recall the design of ongoing clinical trials evaluating novel agents and strategies for MM, and counsel appropriate patients about availability and participation.

  ACCREDITATION STATEMENT
  Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
  
  CREDIT DESIGNATION STATEMENT
  CME credit is no longer available for this issue
  
  AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
  CME credit is no longer available for this issue
  
  HOW TO USE THIS CME ACTIVITY
  Video Program: This CME activity consists of a video component.
  CME credit is no longer available for this issue
  
  CONTENT VALIDATION AND DISCLOSURES
  Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of this activity. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.
  
  FACULTY AND MODERATOR — The following faculty reported relevant financial relationships with ineligible entities:
  
  Faculty
  Larry D Anderson Jr, MD, PhD
  Associate Professor
  Director of Myeloma, Waldenström’s, and Amyloidosis Program
  UT Southwestern Medical Center
  Simmons Comprehensive Cancer Center
  Dallas, Texas
  
  Advisory Committee, Consulting Agreements and Contracted Research: Amgen Inc, Bristol-Myers Squibb Company, Celgene Corporation, GlaxoSmithKline, Janssen Biotech Inc, Karyopharm Therapeutics, Oncopeptides; Data and Safety Monitoring Board/Committee: Prothena.
  
  Morie A Gertz, MD, MACP
  Consultant, Hematology
  Mayo Clinic
  Rochester, Minnesota
  
  Advisory Board: Ionis Pharmaceuticals; Consulting Agreements: Akcea Therapeutics, Alnylam Pharmaceuticals Inc, Prothena; Data and Safety Monitoring Board/Committee: AbbVie Inc, Celgene Corporation; Honoraria: Akcea Therapeutics, Ambry Genetics, Amgen Inc, Celgene Corporation, Janssen Biotech Inc, Karyopharm Therapeutics, Pfizer Inc (to Institution), Sanofi Genzyme; Stock Options: Aurora Biopharma.
  
  Irene M Ghobrial, MD
  Professor of Medicine
  Lavine Family Chair of Preventative Cancer Therapies
  Director, Center for Prevention of Progression of Blood Cancers
  Director, Translational Research in Multiple Myeloma
  Director, Clinical Investigator Research Program
  Director, Michele and Steven Kirsch Laboratory
  Harvard Medical School
  Dana-Farber Cancer Institute
  Boston, Massachusetts
  
  Advisory Committee: Amgen Inc (Europe), Aptitude Health, Bristol-Myers Squibb Company, GlaxoSmithKline, GNS Healthcare, Janssen Biotech Inc, Mind Wrap Medical LLC, Pfizer Inc, Sanofi Genzyme, Takeda Pharmaceuticals USA Inc; Consulting Agreements: AbbVie Inc, Adaptive Biotechnologies Corporation, Amgen Inc (Europe), Aptitude Health, Binding Site, Bristol-Myers Squibb Company, Celgene Corporation, Cellectar Biosciences Inc, CohBar, Curio Science, DAVA Oncology, Genentech, a member of the Roche Group, GlaxoSmithKline, GNS Healthcare, Huron, Janssen Biotech Inc, Janssen Central America and Caribbean, Karyopharm Therapeutics, Magenta Therapeutics, Menarini Silicon Biosystems, Mind Wrap Medical LLC, Multiple Myeloma Research Foundation, Oncopeptides, Pfizer Inc, PureTech Health, Sanofi Genzyme, Sognef, Takeda Pharmaceuticals USA Inc; Contracted Research: Bristol-Myers Squibb Company, Janssen Biotech Inc, Takeda Pharmaceuticals USA Inc; Spouse: CMO and equity holder of Disc Medicine (private company, not publicly traded).
  
  Peter Voorhees, MD
  Professor of Medicine
  Chief, Plasma Cell Disorders Division
  Director of Medical Operations and Outreach Services
  Department of Hematologic Oncology and Blood Disorders
  Levine Cancer Institute, Atrium Health
  Charlotte, North Carolina
  
  Advisory Committee: AbbVie Inc, Bristol-Myers Squibb Company, GlaxoSmithKline, Karyopharm Therapeutics, Pfizer Inc, Sanofi Genzyme; Consulting Agreements: Amgen Inc, Secura Bio; Data and Safety Monitoring Board/Committee: Bristol-Myers Squibb Company, Karyopharm Therapeutics.
  
  Moderator
  
  Robert Z Orlowski, MD, PhD
  Florence Maude Thomas Cancer Research Professor
  Department of Lymphoma and Myeloma
  Professor, Department of Experimental Therapeutics
  Director, Myeloma Section
  Division of Cancer Medicine
  The University of Texas MD Anderson Cancer Center
  Houston, Texas
  
  Advisory Committee: Amgen Inc, BioTheryX Inc, Bristol-Myers Squibb Company, GlaxoSmithKline, Janssen Biotech Inc, Karyopharm Therapeutics, Neoleukin Therapeutics, Oncopeptides, Pfizer Inc, Regeneron Pharmaceuticals Inc, Sanofi Genzyme, Servier Pharmaceuticals LLC, Takeda Pharmaceuticals USA Inc; Clinical Research: CARsgen Therapeutics, Celgene Corporation, Exelixis Inc, Janssen Biotech Inc, Sanofi Genzyme, Takeda Pharmaceuticals USA Inc; Laboratory Research: BioTheryX Inc, Heidelberg Pharma, Pfizer Inc; Ownership Interest: Asylia Therapeutics Inc (founder with equity interest and director, scientific advisory board).
  
  RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.
  
  This educational activity contains discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantors.
  
  TThis activity is supported by educational grants from Bristol-Myers Squibb Company, GlaxoSmithKline, Karyopharm Therapeutics, Oncopeptides and Sanofi Genzyme.
  
  Release date: January 2022
  Expiration date: January 2023