RTP Mobile Logo
Consensus or Controversy? Immune Checkpoint Inhibitors in the Management of Hepatobiliary Cancers — A 2024 Post-ASCO Gastrointestinal Cancers Symposium Review (Webinar Audio Proceedings)
Released March 2024

Featuring perspectives from Dr Robin (Katie) Kelley and Dr Mark Yarchoan. Published March 20, 2024. (Webinar Audio Proceedings)

CE Information and Faculty Disclosures

  • TARGET AUDIENCE
    This program is intended for medical and radiation oncologists, urologists and other healthcare providers involved in the treatment of hepatobiliary cancers.

    LEARNING OBJECTIVES

    • Interrogate recently presented trial results establishing the benefit of anti-PD-L1 antibody therapy in combination with anti-VEGF therapy as adjuvant treatment for patients with hepatocellular carcinoma (HCC) and a high risk of recurrence after curative resection or ablation, and consider the potential role of this strategy in clinical practice.
    • Evaluate emerging Phase III trial results with anti-PD-L1 antibody therapy in combination with anti-VEGF therapy and transarterial chemoembolization for patients with unresectable HCC who are eligible for embolization.
    • Appreciate published and recently updated Phase III data with immune checkpoint inhibitors as first-line therapy for unresectable or metastatic HCC, and discuss how available regimens can be optimally integrated into patient care.
    • Understand the rationale for and available data with anti-PD-1/PD-L1 antibodies in combination with anti-CTLA-4 antibodies for patients with HCC, and determine the current role of these novel regimens in clinical practice.
    • Discuss the biological justification for the evaluation of immune checkpoint inhibitors for patients with advanced biliary tract cancers (BTCs), and provide appropriate counsel regarding the risks and benefits of anti-PD-1/PD-L1 antibody-based approaches as first-line treatment.
    • Recall available and emerging data with immune checkpoint inhibitor-based strategies currently in clinical testing for HCC and BTCs, and refer eligible patients for trial participation.

    ACCREDITATION STATEMENT
    Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

    CREDIT DESIGNATION STATEMENT
    Audio Program: Research To Practice designates this enduring material for a maximum of 1.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Video Program: Research To Practice designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    AMERICAN BOARD OF INTERNAL MEDICINE (ABIM) — MAINTENANCE OF CERTIFICATION (MOC)
    Successful completion of these CME activities, which includes participation in the evaluation components and a short post-test, enables the participant to earn up to 1.75 (audio) and 1.25 (video) Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for each activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

    Please note, these programs have been specifically designed for the following ABIM specialty: medical oncology.

    AMERICAN BOARD OF SURGERY (ABS) — CONTINOUS CERTIFICATION (CC)
    Successful completion of these CME activities, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and Self-Assessment requirement(s) of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABS credit.

    Please note, these programs have been specifically designed for the following ABS practice area: complex general surgical oncology.

    PRIVACY POLICY
    Personal information and data sharing: Research To Practice aggregates deidentified user data for program-use analysis, program development, activity planning and site improvement. We may provide aggregate and deidentified data to third parties, including commercial supporters. We do not share or sell personally identifiable information to any unaffiliated third parties or commercial supporters. Please see our privacy policy at ResearchToPractice.com/Privacy-Policy for more information.

    HOW TO USE THIS CME ACTIVITY
    Audio Program: This CME activity consists of an audio component. To receive credit, the participant should review the CME information, listen to the MP3s, review the downloadable slide set, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/ASCOGI24/Hepatobiliary2/CME. The corresponding video program is available as an alternative at ResearchToPractice.com/ASCOGI24/Hepatobiliary2/Video.

    Video Program: This CME activity consists of a video component. To receive credit, the participant should review the CME information, watch the video, complete the post-test with a score of 80% or better and fill out the evaluation located at ResearchToPractice.com/ASCOGI24/Hepatobiliary2/Video/CME. The corresponding audio program is available as an alternative at ResearchToPractice.com/ASCOGI24/Hepatobiliary2.

    CONTENT VALIDATION AND DISCLOSURES
    Research To Practice (RTP) is committed to providing its participants with high-quality, unbiased and state-of-the-art education and adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of an accredited continuing education activity, including faculty, planners, reviewers and others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of these activities. In addition, all activity content is reviewed by RTP scientific staff and an external, independent physician reviewer for fair balance, scientific objectivity of studies referenced and patient care recommendations.

    FACULTY — The following faculty reported relevant financial relationships with ineligible entities:

    Robin (Katie) Kelley, MD
    Professor of Clinical Medicine, Division of Hematology/Oncology
    Helen Diller Family Comprehensive Cancer Center
    University of California, San Francisco (UCSF)
    San Francisco, California

    Advisory Committees (Payments to Insitution): Agios Pharmaceuticals Inc, AstraZeneca Pharmaceuticals LP, Exelixis Inc, Ipsen Biopharmaceuticals Inc, Merck; Consulting Agreements (Payments to Self): Compass Therapeutics, Exact Sciences Corporation, J-Pharma Co Ltd, Kinnate Biopharma, Regeneron Pharmaceuticals Inc, Tyra Biosciences; Contracted Research (Payment to Institution for Trial Conduct): Agios Pharmaceuticals Inc, AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, Compass Therapeutics, EMD Serono Inc, Exelixis Inc, Genentech, a member of the Roche Group, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, Merck, Partner Therapeutics, QED Therapeutics, Servier Pharmaceuticals LLC, Surface Oncology, Taiho Oncology Inc, Tyra Biosciences; Independent Data Monitoring Committees (Unpaid Service): Genentech, a member of the Roche Group, Merck.

    Mark Yarchoan, MD
    Associate Professor of Medical Oncology
    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    Baltimore, Maryland

    Consulting Agreements: AstraZeneca Pharmaceuticals LP, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group; Co-Founder with Equity: Adventris Pharmaceuticals; Research Funding (to Johns Hopkins): Bristol Myers Squibb, Exelixis Inc, Genentech, a member of the Roche Group, Incyte Corporation.

    MODERATOR — Dr Love is president and CEO of Research To Practice. Research To Practice receives funds in the form of educational grants to develop CME activities from the following companies: AbbVie Inc, Adaptive Biotechnologies Corporation, ADC Therapeutics, Agios Pharmaceuticals Inc, Alexion Pharmaceuticals, Amgen Inc, Array BioPharma Inc, a subsidiary of Pfizer Inc, Astellas, AstraZeneca Pharmaceuticals LP, Aveo Pharmaceuticals, Bayer HealthCare Pharmaceuticals, BeiGene Ltd, BeyondSpring Pharmaceuticals Inc, Blueprint Medicines, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Celgene Corporation, Clovis Oncology, Coherus BioSciences, CTI Biopharma, a Sobi company, Daiichi Sankyo Inc, Eisai Inc, Elevation Oncology Inc, EMD Serono Inc, Epizyme Inc, Exact Sciences Corporation, Exelixis Inc, Five Prime Therapeutics Inc, Foundation Medicine, G1 Therapeutics Inc, Genentech, a member of the Roche Group, Genmab US Inc, Gilead Sciences Inc, Grail Inc, GSK, Halozyme Inc, Helsinn Healthcare SA, ImmunoGen Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Janssen Biotech Inc, administered by Janssen Scientific Affairs LLC, Jazz Pharmaceuticals Inc, Karyopharm Therapeutics, Kite, A Gilead Company, Kronos Bio Inc, Legend Biotech, Lilly, Loxo Oncology Inc, a wholly owned subsidiary of Eli Lilly & Company, MEI Pharma Inc, Merck, Mersana Therapeutics Inc, Mirati Therapeutics Inc, Mural Oncology Inc, Natera Inc, Novartis, Novartis Pharmaceuticals Corporation on behalf of Advanced Accelerator Applications, Novocure Inc, Oncopeptides, Pfizer Inc, Pharmacyclics LLC, an AbbVie Company, Puma Biotechnology Inc, Regeneron Pharmaceuticals Inc, R-Pharm US, Sanofi, Seagen Inc, Servier Pharmaceuticals LLC, SpringWorks Therapeutics Inc, Stemline Therapeutics Inc, Sumitomo Dainippon Pharma Oncology Inc, Taiho Oncology Inc, Takeda Pharmaceuticals USA Inc, TerSera Therapeutics LLC, Tesaro, A GSK Company, TG Therapeutics Inc, Turning Point Therapeutics Inc, Verastem Inc, and Zymeworks Inc.

    SURVEY PARTICIPANTS
    Ghassan Abou-Alfa, MD, MBAConsulting Agreements: AstraZeneca Pharmaceuticals LP, Autem Therapeutics, Berry Genomics, BioNTech SE, Boehringer Ingelheim Pharmaceuticals Inc, Bristol Myers Squibb, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, Incyte Corporation, Ipsen Biopharmaceuticals Inc, Merck, Merus BV, Neogene Therapeutics, Novartis, Servier Pharmaceuticals LLC, Tempus, Vector Pharma, Yiviva; Contracted Research: Agenus Inc, Arcus Biosciences, AstraZeneca Pharmaceuticals LP, BioNTech SE, Bristol Myers Squibb, Digestive Care Inc, Elicio Therapeutics, Genentech, a member of the Roche Group, Helsinn Healthcare SA, Puma Biotechnology Inc, QED Therapeutics, Yiviva; Nonrelevant Financial Relationship: Parker Institute for Cancer Immunotherapy. Thomas A Abrams, MDAdvisory Committee: AstraZeneca Pharmaceuticals LP; Consulting Agreements: Eisai Inc, Exelixis Inc, HistoSonics; Contracted Research: AbbVie Inc, AstraZeneca Pharmaceuticals LP. Ahmed Omar Kaseb, MD, CMQAdvisory Committees, Consulting Agreements and Contracted Research: AstraZeneca Pharmaceuticals LP, Bayer HealthCare Pharmaceuticals, Bristol Myers Squibb, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, Merck. Daneng Li, MDConsulting Agreements: AbbVie Inc, AstraZeneca Pharmaceuticals LP, Delcath Systems Inc, Eisai Inc, Exelixis Inc, Genentech, a member of the Roche Group, Merck, Sumitomo Dainippon Pharma Oncology Inc, TriSalus Life Sciences; Contracted Research: AstraZeneca Pharmaceuticals LP. Stacey Stein, MDAdvisory Committees: AbbVie Inc, Eisai Inc, Genentech, a member of the Roche Group; Consulting Agreements: AstraZeneca Pharmaceuticals LP, Merck; Data and Safety Monitoring Boards/Committees: Aethlon Medical Inc, Genentech, a member of the Roche Group. Arndt Vogel, MD, PhDConsultancy and Advisory; Speaker: Amgen Inc, AstraZeneca Pharmaceuticals LP, BeiGene Ltd, Boehringer Mannheim, Bristol Myers Squibb, Eisai Inc, Incyte Corporation, Ipsen Biopharmaceuticals Inc, MSD, Pierre Fabre, Roche Laboratories Inc, Servier Pharmaceuticals LLC, Taiho Oncology Inc.

    RESEARCH TO PRACTICE CME PLANNING COMMITTEE MEMBERS, STAFF AND REVIEWERS — Planners, scientific staff and independent reviewers for Research To Practice have no relevant conflicts of interest to disclose.

    These educational activities contain discussion of published and/or investigational uses of agents that are not indicated by the Food and Drug Administration. Research To Practice does not recommend the use of any agent outside of the labeled indications. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications and warnings. The opinions expressed are those of the presenters and are not to be construed as those of the publisher or grantor.

    These activities are supported by an educational grant from AstraZeneca Pharmaceuticals LP.

    Release date: March 2024
    Expiration date: March 2025

    After completing the post-test, learners may download and review the answers here in order to identify further areas of study.

Acknowledge and close

Listen to audio
(WIFI is recommended for best performance):