Recommended Obinutuzumab and Rituximab Dosing

The recommended dose and schedule of obinutuzumab for the approved regimen with chlorambucil in CLL is:

Cycle 1: 100 mg intravenously on day 1, 900 mg on day 2 and 1,000 mg on days 8 and 15

Cycles 2-6: 1,000 mg administered intravenously every 28 days

The recommended dose and schedule of rituximab for the approved regimen with fludarabine and cyclophosphamide (FC) in CLL is:

375 mg/m² the day prior to the initiation of FC chemotherapy, then 500 mg/m² on day 1 of cycles 2-6 (every 28 days)

http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm373263.htm

http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/103705s5367s5388lbl.pdf